HLA - B18与淋巴细胞中异丙肾上腺素刺激的环磷酸腺苷（cAMP）水平降低有关。
HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.
作者信息
Erickson R P, Pairitz G L, Karolyi J M, Kapur J J, Odenheimer D J, Schultz J S, Sing C F
出版信息
Am J Hum Genet. 1985 Jan;37(1):124-32.
One hundred fifty-nine individuals were typed for HLA-A and B antigens and levels of isoproterenol-stimulated, lymphocyte cAMP. No significant age, sex, or caffeine effects on the natural log of the lymphocyte cAMP variable (ln cAMP) were found. A comparison of mean ln cAMP levels between individuals who carried a particular antigen (homozygous or heterozygous) and individuals who did not carry the antigen identified a highly significant decrease in ln cAMP levels associated with the HLA-B18 antigen. We estimated that 18.9% of the variability in ln cAMP was attributable to the HLA-B18 antigen. In addition, 38% of the variability in ln cAMP was attributable to factors that aggregate in families that were independent of the HLA-B18 effect. A weaker association of A10 with lymphocyte cAMP might be due to linkage disequilibrium between A10 and B18.
对159名个体进行了HLA - A和B抗原分型以及异丙肾上腺素刺激的淋巴细胞环磷酸腺苷（cAMP）水平检测。未发现年龄、性别或咖啡因对淋巴细胞cAMP变量的自然对数（ln cAMP）有显著影响。对携带特定抗原（纯合或杂合）的个体与未携带该抗原的个体之间的平均ln cAMP水平进行比较，发现与HLA - B18抗原相关的ln cAMP水平显著降低。我们估计ln cAMP变异性的18.9%可归因于HLA - B18抗原。此外，ln cAMP变异性的38%可归因于在家族中聚集的、独立于HLA - B18效应的因素。A10与淋巴细胞cAMP的较弱关联可能是由于A10和B18之间的连锁不平衡。
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