Su Changhai, Liu Yang, Zhang Haiwen, Xiao Bin, Ba Te'er
Dept. of Clinical Pharmacy, Ordos Central Hospital, Ordos, Inner Mongolia, P.R. China.
Dept. of Internal Medicine, Ordos Central Hospital, Ordos, Inner Mongolia, P.R. China.
Iran J Public Health. 2018 Mar;47(3):335-341.
This study aimed to investigate the effects of antibiotic application on the intestinal flora in elderly hypertension patients with infectious diseases.
A total of 2350 infected patients treated in Ordos Central Hospital (Inner Mongolia, China) from January 2010 to August 2016 were retrospectively analyzed and 790 healthy hypertension patients were selected as the control group. The 2350 patients were assigned into group A and B based on the administration with narrow-spectrum antibiotic or broad-spectrum antibiotic. The feces specimens of patients at the 1st, 5th, 9th and 14th day after antibiotic treatment were collected to analyze the bacteriological data and the cases of intestinal flora imbalance after applying the narrow-spectrum and broad-spectrum antibiotic were compared and the differences in the bacterial colony compositions of intestinal floras from those of the healthy hypertension patients at the same period were analyzed.
The ratio of intestinal flora imbalance was 50.4% after applying antibiotic in patients from group A and 78.3% in group B. grade I and II imbalance were predominant in group A and grade III imbalance was the most severe one in group B (<0.05). Compared with the intestinal flora in healthy elderly hypertension patients, the ratio of the primary composition flora of patients with imbalanced intestinal flora was changed obviously.
The application of narrow-spectrum antibiotic and shortening the application time of antibiotic can more effectively protect the normal intestinal flora of elderly hypertension patients.
本研究旨在探讨抗生素应用对老年高血压合并感染性疾病患者肠道菌群的影响。
回顾性分析2010年1月至2016年8月在鄂尔多斯市中心医院（中国内蒙古）接受治疗的2350例感染患者，并选取790例健康高血压患者作为对照组。根据使用窄谱抗生素或广谱抗生素将2350例患者分为A组和B组。收集抗生素治疗后第1、5、9和14天患者的粪便标本，分析细菌学数据，比较使用窄谱和广谱抗生素后肠道菌群失调的病例，并分析同期肠道菌群细菌菌落组成与健康高血压患者的差异。
A组患者应用抗生素后肠道菌群失调比例为50.4%，B组为78.3%。A组以I级和II级失调为主，B组以III级失调最为严重（<0.05）。与健康老年高血压患者的肠道菌群相比，肠道菌群失调患者主要组成菌群的比例发生了明显变化。
应用窄谱抗生素并缩短抗生素应用时间能更有效地保护老年高血压患者的正常肠道菌群。
