Tenovuo J, Mäkinen K K, Sievers G
Antimicrob Agents Chemother. 1985 Jan;27(1):96-101. doi: 10.1128/AAC.27.1.96.
An oral periodontopathic bacterium, Bacillus cereus, was inhibited both by lactoperoxidase (LP) and myeloperoxidase (MP) antimicrobial systems. With the LP-SCN--H2O2 system, the growth inhibition was directly proportional to the amount of OSCN- ions present. The OSCN-, which is the principal oxidation product of the LP (or MP)-SCN--H2O2 system at neutral pH, is a normal component of human saliva. The oxidation products of both peroxidase systems inhibited the growth of the bacteria. This inhibition was associated with reduced extracellular release of collagenase activity from the cells. With LP, the antimicrobial efficiency of the oxidizable substrates was SCN- greater than I-, and with MP, the efficiency was I- greater than Cl- greater than SCN-, respectively. LP did not oxidize Cl-.
一种口腔牙周病原菌——蜡样芽孢杆菌，受到乳过氧化物酶（LP）和髓过氧化物酶（MP）抗菌系统的抑制。在LP - SCN⁻ - H₂O₂系统中，生长抑制与存在的OSCN⁻离子量直接成正比。OSCN⁻是LP（或MP）- SCN⁻ - H₂O₂系统在中性pH值下的主要氧化产物，是人类唾液的正常成分。两种过氧化物酶系统的氧化产物均抑制细菌生长。这种抑制与细胞外胶原酶活性释放减少有关。对于LP，可氧化底物的抗菌效率为SCN⁻大于I⁻；对于MP，效率分别为I⁻大于Cl⁻大于SCN⁻。LP不氧化Cl⁻。
