Tenovuo J, Mansson-Rahemtulla B, Pruitt K M, Arnold R
Infect Immun. 1981 Oct;34(1):208-14. doi: 10.1128/iai.34.1.208-214.1981.
Resting human whole saliva inhibited acid production by glucose-stimulated, homologous plaque. The degree of inhibition of plaque acid production correlated positively with the concentration of hypothiocyanite (OSCN-) ions in saliva. Supplementation of saliva with an appropriate combination of thiocyanate and hydrogen peroxide resulted in a significant increase in the concentration of OSCN- ions and in more effective inhibition of plaque acid production. In most cases, the inhibition was complete when the supplements were added directly to saliva-plaque mixtures. Acid production resumed when the inhibitory effect of OSCN- was reversed by addition of thiols. Among the oral defense factors, the salivary lactoperoxidase system seems to play an important role by producing highly reactive antibacterial products (including OSCN-) which can regulate bacterial metabolism in the human mouth. The concentration of OSCN- in normal human whole saliva seems to be just below the threshold level required for plaque inhibition. Therefore, enhancement of this system in vivo may be effective in the regulation of plaque acid production.
人静息全唾液可抑制葡萄糖刺激的同源菌斑产酸。菌斑产酸的抑制程度与唾液中次硫氰酸盐（OSCN-）离子浓度呈正相关。向唾液中补充硫氰酸盐和过氧化氢的适当组合可导致OSCN-离子浓度显著增加，并更有效地抑制菌斑产酸。在大多数情况下，当将补充剂直接添加到唾液-菌斑混合物中时，抑制作用是完全的。当通过添加硫醇逆转OSCN-的抑制作用时，产酸恢复。在口腔防御因子中，唾液中的乳过氧化物酶系统似乎通过产生高反应性抗菌产物（包括OSCN-）发挥重要作用，这些产物可调节人类口腔中的细菌代谢。正常人全唾液中OSCN-的浓度似乎略低于抑制菌斑所需的阈值水平。因此，体内增强该系统可能对调节菌斑产酸有效。
