Labusca Luminita, Herea Dumitru Daniel, Mashayekhi Kaveh
Orthopedics and Traumatology Clinic, Emergency County Hospital Saint Spiridon Iasi Romania, Iasi 700000, Romania.
Stem Cell Laboratory, National Institute of Research and Development for Technical Physics (NIRDTP), Iasi 700349, Romania.
World J Stem Cells. 2018 May 26;10(5):43-56. doi: 10.4252/wjsc.v10.i5.43.
The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications. Stem-cell-mediated delivery of genes, proteins or small molecules takes advantage of the innate capability of stem cells to migrate and home to injury sites. As the native migratory properties are affected by expansion, the existent methods for enhancing stem cell targeting capabilities (modified culture methods, genetic modification, cell surface engineering) are described. The role of various nanoparticles in equipping stem cells with therapeutic small molecules is revised together with their class-specific advantages and shortcomings. Modalities to circumvent common challenges when designing a stem-cell-mediated targeted delivery system are described as well as future prospects in using this approach for regenerative medicine applications.
将干细胞用作治疗剂的载体是一种针对感兴趣的组织或器官的有吸引力的方式。将细胞与各种信息分子作为治疗剂联合递送有可能增强、调节甚至启动局部或全身修复过程，提高干细胞在再生医学应用中的效率。干细胞介导的基因、蛋白质或小分子递送利用了干细胞迁移并归巢到损伤部位的固有能力。由于天然迁移特性受扩增影响，本文描述了增强干细胞靶向能力的现有方法（改良培养方法、基因修饰、细胞表面工程）。综述了各种纳米颗粒在为干细胞配备治疗性小分子方面的作用及其类别特异性优缺点。描述了设计干细胞介导的靶向递送系统时规避常见挑战的方法以及将该方法用于再生医学应用的未来前景。
