Karst Sonja G, Lammer Jan, Radwan Salma H, Kwak Hanna, Silva Paolo S, Burns Stephen A, Aiello Lloyd Paul, Sun Jennifer K
Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Int J Endocrinol. 2018 May 2;2018:7492946. doi: 10.1155/2018/7492946. eCollection 2018.
To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques.
Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images.
Individual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging.
Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT.
AOSLO imaging provides detailed, noninvasive visualization of DR lesions enhancing the assessment of morphological characteristics. These unique AOSLO attributes may enable new insights into the pathological changes of DR in response to disease onset, development, regression, and response to therapy.
利用自适应光学扫描激光检眼镜（AOSLO）对糖尿病视网膜病变（DR）的标志性病变进行特征描述，并将AOSLO检查结果与标准成像技术的结果进行比较。
横断面研究，纳入34名研究参与者的35只眼睛。对患有DR的眼睛进行AOSLO共聚焦和多重散射光（MSL）成像。获取每个病变的彩色眼底照片（CF）、黄斑区红外图像（Spectralis，海德堡）以及Spectralis光谱域光学相干断层扫描（SDOCT）B扫描图像，并将其与相应的AOSLO图像配准。
通过AOSLO成像对单个病变进行特征描述。将AOSLO表现与CF和SDOCT成像进行比较。
所描述的病变包括52个微动脉瘤（MA）、20个视网膜内微血管异常（IRMA）、7个新生血管（NV）、11个硬性渗出（HE）、5个点状/斑状出血（HEM）、4个棉絮斑（CWS）和14个视网膜内囊肿。AOSLO能够评估血管病变中的灌注情况，并能够识别在CF或SDOCT上无法看到的血管病变。
AOSLO成像提供了DR病变的详细、无创可视化，增强了对形态学特征的评估。这些独特的AOSLO特性可能有助于对DR在疾病发生、发展、消退及治疗反应过程中的病理变化获得新的认识。
