Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey.
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Oxid Med Cell Longev. 2018 May 2;2018:7864269. doi: 10.1155/2018/7864269. eCollection 2018.
L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of was reported to display marked pharmacological effects and great variation in chemical composition depending on growing locations but mostly contained limonene, linalool, and -myrcene. Phytochemically, is rich in -synephrine, an alkaloid, and many health-giving secondary metabolites such as flavonoids. Animal studies have demonstrated a low affinity of -synephrine for adrenergic receptors and an even lower affinity in human models. The present review focuses on the different biological activities of the in animal and human models in the form of extract and its pure secondary metabolites. Finally, it is concluded that both the extract and isolated compounds have no unwanted effects in human at therapeutic doses and, therefore, can confidently be used in various dietary formulations.
枳（芸香科），俗称酸橙，具有多种治疗潜力。这些生物学凭证包括抗癌、抗焦虑、抗肥胖、抗菌、抗氧化、杀虫和抗糖尿病活性。报道称， 的精油具有显著的药理作用和化学成分的巨大差异，这取决于生长地点，但主要含有柠檬烯、芳樟醇和 - 月桂烯。植物化学上， 富含 - 辛弗林，一种生物碱，以及许多有益的次生代谢物，如类黄酮。动物研究表明， - 辛弗林对肾上腺素能受体的亲和力较低，在人体模型中的亲和力甚至更低。本综述重点介绍了 提取物及其纯次生代谢物在动物和人体模型中的不同生物学活性。最后得出结论，提取物和分离化合物在治疗剂量下对人体没有不良影响，因此可以放心地用于各种饮食配方中。
