Holloway W R, Thor D H
Pharmacol Biochem Behav. 1985 Mar;22(3):421-6. doi: 10.1016/0091-3057(85)90043-7.
The effects of caffeine, 2-chloroadenosine and haloperidol and their interaction on activity, social investigation, and two measures of play fighting (crossover and pinning), were investigated in juvenile male rats. Caffeine (20 mg/kg) increased activity, decreased crossover and pinning, but had no effect on social investigation. Both 2-chloroadenosine (0-10 mg/kg) and haloperidol (0-10 mg/kg) depressed activity, social investigation, crossover and pinning. When given together in varying dosages, caffeine and 2-chloroadenosine had behavioral effects suggestive of a competitive interaction between the two drugs. In contrast, the effects of haloperidol were not appreciably altered by simultaneous caffeine treatment. These results suggest that the influence of caffeine and 2-chloroadenosine on activity, social investigation and play fighting involve interaction with adenosine receptors.
在幼年雄性大鼠中，研究了咖啡因、2-氯腺苷和氟哌啶醇及其相互作用对活动、社交探究以及两种打斗玩耍行为（交叉和压制）指标的影响。咖啡因（20毫克/千克）增加了活动量，减少了交叉和压制行为，但对社交探究没有影响。2-氯腺苷（0 - 10毫克/千克）和氟哌啶醇（0 - 10毫克/千克）均降低了活动量、社交探究、交叉和压制行为。当以不同剂量联合给药时，咖啡因和2-氯腺苷产生的行为效应表明这两种药物之间存在竞争性相互作用。相比之下，同时给予咖啡因处理并未明显改变氟哌啶醇的效应。这些结果表明，咖啡因和2-氯腺苷对活动、社交探究和打斗玩耍的影响涉及与腺苷受体的相互作用。
