Korkmaz Selda, Bilecenoglu Nedime Tugce, Aksu Murat, Yoldas Tahir Kurtulus
Department of Neurology, Istanbul Aydin University, Faculty of Medicine, Istanbul, Turkey.
Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey.
Sleep Disord. 2018 May 16;2018:8713409. doi: 10.1155/2018/8713409. eCollection 2018.
One of the main hypotheses on the development of daytime sleepiness (ES) is increased arousal in obstructive sleep apnea (OSA). Cyclic alternating pattern (CAP) is considered to be the main expression of sleep microstructure rather than arousal. Therefore, we aimed to investigate whether there is any difference between OSA patients with versus without ES in terms of the parameters of sleep macro- and microstructure and which variables are associated with Epworth Sleepiness Scale (ESS) score.
Thirty-eight male patients with moderate to severe OSA were divided into two subgroups by having been used to ESS as ES or non-ES.
There was no difference between two groups in clinical characteristics and macrostructure parameters of sleep. However, ES group had significantly higher CAP rate, CAP duration, number of CAP cycles, and duration and rate of the subtypes A2 ( = 0.033, 0.019, 0.013, and 0.019, respectively) and lower mean phase B duration ( = 0.028) compared with non-ES group. In correlation analysis, ESS score was not correlated with any CAP measure.
OSA patients with ES have increased CAP measures rather than those without ES.
关于日间嗜睡（ES）发生的主要假说之一是阻塞性睡眠呼吸暂停（OSA）时觉醒增加。周期性交替模式（CAP）被认为是睡眠微观结构而非觉醒的主要表现形式。因此，我们旨在研究伴有与不伴有ES的OSA患者在睡眠宏观和微观结构参数方面是否存在差异，以及哪些变量与艾普沃思嗜睡量表（ESS）评分相关。
38例中重度OSA男性患者根据ESS分为ES组和非ES组两个亚组。
两组患者的临床特征和睡眠宏观结构参数无差异。然而，与非ES组相比，ES组的CAP率、CAP持续时间、CAP周期数以及A2亚型的持续时间和发生率（分别为P = 0.033、0.019、0.013和0.019）显著更高，而平均B期持续时间更低（P = 0.028）。在相关性分析中，ESS评分与任何CAP指标均无相关性。
伴有ES的OSA患者的CAP指标增加，而非ES患者则不然。
