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神经退行性变中的微小RNA:当前研究发现与潜在影响

microRNAs in Neurodegeneration: Current Findings and Potential Impacts.

作者信息

Sharma Salil, Lu Hui-Chen

机构信息

Department of Psychological and Brain Sciences, The Linda and Jack Gill Center for Bimolecular Sciences, Indiana University, Bloomington, IN 47405, USA.

出版信息

J Alzheimers Dis Parkinsonism. 2018;8(1). doi: 10.4172/2161-0460.1000420. Epub 2018 Jan 23.

Abstract

Significant advancements have been made in unraveling and understanding the non-coding elements of the human genome. New insights into the structure and function of noncoding RNAs have emerged. Their relevance in the context of both physiological cellular homeostasis and human diseases is getting appreciated. As a result, exploration of noncoding RNAs, in particular microRNAs (miRs), as therapeutic agents or targets of therapeutic strategies is under way. This review summarizes and discusses in depth the current literature on the role of miRs in neurodegenerative diseases.

摘要

在解开和理解人类基因组的非编码元件方面已经取得了重大进展。对非编码RNA的结构和功能有了新的认识。它们在生理细胞稳态和人类疾病背景下的相关性正在得到认可。因此,正在探索将非编码RNA,特别是微小RNA(miRs)作为治疗剂或治疗策略的靶点。这篇综述总结并深入讨论了目前关于miRs在神经退行性疾病中作用的文献。

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