Chieffi Paolo
Dipartimento di Psicologia, Università della Campania, Caserta, Italy.
Intractable Rare Dis Res. 2018 May;7(2):141-144. doi: 10.5582/irdr.2018.01018.
A critical step for maintenance of genetic stability is chromosome segregation, which requires a high coordination of cellular processes. Loss of mitotic regulation is a possible cause of aneuploidy in human epithelial malignancy and it is thought to create an abnormal nuclear morphology in cancer cells. Serine/threonine protein kinase Aurora B gene plays a regulatory role from G2 to cytokinesis, encompassing key cell cycle events such as centrosome duplication, chromosome bi-orientation, and segregation. The overexpression of Aurora B has been observed in several tumour types, and has been linked with a poor prognosis for cancer patients. Therapeutic inhibition of Aurora kinase showed great promise as a probable anticancer regime because of its important role during cell division.
维持遗传稳定性的关键步骤是染色体分离，这需要细胞过程的高度协调。有丝分裂调控的丧失是人类上皮恶性肿瘤中非整倍体的一个可能原因，并且被认为会在癌细胞中产生异常的核形态。丝氨酸/苏氨酸蛋白激酶Aurora B基因在从G2期到胞质分裂的过程中发挥调节作用，涵盖了诸如中心体复制、染色体双定向和分离等关键细胞周期事件。在几种肿瘤类型中都观察到了Aurora B的过表达，并且它与癌症患者的不良预后有关。由于Aurora激酶在细胞分裂过程中的重要作用，对其进行治疗性抑制作为一种可能的抗癌方案显示出了巨大的前景。
