Azam Hamza, Shahrestani Sara, Phan Kevin
Faculty of Medicine, Westmead Clinical School, University of Sydney, Sydney, Australia.
Liverpool Hospital, Liverpool, Sydney, Australia.
Ann Transl Med. 2018 Apr;6(8):148. doi: 10.21037/atm.2018.03.16.
There have been increasing reports of increased risk of alcohol use disorder (AUD) in the post bariatric surgery patient. The aim of this systematic review and meta-analysis is to observe the rate of AUD in the postoperative period following bariatric surgery for weight management.
Electronic searches were performed using six databases from their dates of inception to January 2017. Studies observing the trend in AUD post bariatric surgery were identified. Data for relevant endpoint was extracted and analysed.
Ten studies were identified for inclusion of analyses. One year post operatively pooled odds were 1.004 [95% confidence interval (CI), 0.921-1.094; P=0.935], with no significant difference found in the proportion of patients with AUD at 1 year pre-surgery. Two years post operatively pooled odds were 0.981 (95% CI, 0.843-1.142; P=0.806), with no significant difference found in the proportion of patients with AUD at 2 years pre-surgery. Three years post operatively pooled odds were 1.825 (95% CI, 1.53-2.178; P<0.001) with a significant increase in AUD particularly with gastric bypass surgery.
In conclusion, prevalence of AUD increases in patients undergoing gastric bypass surgery but not gastric banding. The risk of AUD was found to not be significantly increased in the first 2 years postoperatively but increasing after this period.
越来越多的报告指出，减肥手术后患者患酒精使用障碍（AUD）的风险增加。本系统评价和荟萃分析的目的是观察减肥手术用于体重管理后的术后AUD发生率。
使用六个数据库从其创建日期至2017年1月进行电子检索。确定观察减肥手术后AUD趋势的研究。提取并分析相关终点的数据。
确定了十项研究纳入分析。术后一年合并优势比为1.004[95%置信区间（CI），0.921 - 1.094；P = 0.935]，术前1年AUD患者比例无显著差异。术后两年合并优势比为0.981（95%CI，0.843 - 1.142；P = 0.806），术前2年AUD患者比例无显著差异。术后三年合并优势比为1.825（95%CI，1.53 - 2.178；P < 0.001），AUD显著增加，尤其是胃旁路手术。
总之，接受胃旁路手术而非胃束带手术的患者中AUD患病率增加。发现术后前两年AUD风险没有显著增加，但在此之后风险增加。
