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心包入路及心肌保护对术后右心室功能降低的影响。

The impact of pericardial approach and myocardial protection onto postoperative right ventricle function reduction.

作者信息

Zanobini Marco, Loardi Claudia, Poggio Paolo, Tamborini Gloria, Veglia Fabrizio, Di Minno Alessandro, Myasoedova Veronika, Mammana Liborio Francesco, Biondi Raoul, Pepi Mauro, Alamanni Francesco, Saccocci Matteo

机构信息

Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, University of Milan, Via Parea, 4, 20138, Milan, Italy.

Heart Center, University Hospital of Zürich, University of Zürich, Zürich, CH, Switzerland.

出版信息

J Cardiothorac Surg. 2018 Jun 5;13(1):55. doi: 10.1186/s13019-018-0726-5.

Abstract

BACKGROUND

The reduction of RV function after cardiac surgery is a well-known phenomenon. It could persist up-to one year after the operation and often leads to an incomplete recovery at follow-up echocardiographic control. The aim of the present study is to analyze the impact of different modalities of pericardial incision (lateral versus anterior) and of myocardial protection protocols (Buckberg versus Custodiol) onto postoperative RV dynamic by relating two- and three-dimensional echocardiographic parameters in patients undergoing mitral valve repair through minimally invasive or traditional surgery approach.

METHODS

We have analyzed 44 consecutive patients with severe degenerative mitral regurgitation who underwent mitral reparation with different surgical approach and cardioplegia type: Group 1 (17 pts): sternotomy with Buckberg cardioplegia protocol; Group 2 (10 pts): sternotomy with Custodiol cardioplegia; Group 3 (17 pts): mini-invasive surgery with Custodiol cardioplegia. Two-dimensional transthoracic echocardiography was performed pre- and 6 months post-surgery to evaluate RV function by tricuspid annular plane systolic excursion (TAPSE).

RESULTS

All patients underwent successful and uneventful. A postoperative TAPSE reduction was found in all groups. However, mini-invasive patients experienced a significant reduced variation versus traditional surgery.

CONCLUSIONS

Mini-invasive mitral repair, with lateral incision of pericardium, reduces postoperative TAPSE fall, while cardioplegia protocol fails to have an impact onto longitudinal RV function. In our study, the RV seems to experience a clinically irrelevant geometrical modification too, whose entity appears to be less evident in case of lateral pericardial approach. These results could strengthen the use of minimally invasive approach also to preserve RV function.

摘要

背景

心脏手术后右心室功能降低是一种众所周知的现象。它可能在术后持续长达一年,并且在随访超声心动图检查时常常导致恢复不完全。本研究的目的是通过关联接受二尖瓣修复的患者采用微创或传统手术方法时的二维和三维超声心动图参数,分析心包切开的不同方式(外侧与前侧)和心肌保护方案(Buckberg与Custodiol)对术后右心室动态的影响。

方法

我们分析了44例连续的严重退行性二尖瓣反流患者,他们采用不同的手术方法和心脏停搏类型进行二尖瓣修复:第1组(17例患者):采用Buckberg心脏停搏方案的胸骨切开术;第2组(10例患者):采用Custodiol心脏停搏的胸骨切开术;第3组(17例患者):采用Custodiol心脏停搏的微创手术。在术前和术后6个月进行二维经胸超声心动图检查,通过三尖瓣环平面收缩期位移(TAPSE)评估右心室功能。

结果

所有患者手术均成功且过程顺利。所有组均发现术后TAPSE降低。然而,与传统手术相比,微创患者的变化显著减小。

结论

采用心包外侧切口的微创二尖瓣修复可减少术后TAPSE下降,而心脏停搏方案对右心室纵向功能没有影响。在我们的研究中,右心室似乎也经历了临床上无关紧要的几何形态改变,在采用心包外侧入路时这种改变的程度似乎不太明显。这些结果可能会加强微创方法在保留右心室功能方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048e/5987597/57c1cba1ed0d/13019_2018_726_Fig1_HTML.jpg

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