Siniscalco Dario, Schultz Stephen, Brigida Anna Lisa, Antonucci Nicola
Department of Experimental Medicine, University of Campania, 80138 Naples, Italy.
Italian Group for Study Autism-GISA, 25018 Brescia, Italy.
Pharmaceuticals (Basel). 2018 Jun 4;11(2):56. doi: 10.3390/ph11020056.
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dysfunction. Several cell types are enrolled to trigger and sustain these processes. Neuro-inflammation and neuro-immune abnormalities have now been established in ASD as key factors in its development and maintenance. In this review, we will explore inflammatory conditions, dysfunctions in neuro-immune cross-talk, and immune system treatments in ASD management.
自闭症谱系障碍（ASD）的特征是社交沟通和互动持续存在缺陷，以及行为、兴趣或活动的局限重复模式。强烈的炎症状态与ASD相关。这种炎症状况通常与免疫系统功能障碍有关。多种细胞类型参与触发和维持这些过程。神经炎症和神经免疫异常现已被确认为ASD发展和维持的关键因素。在本综述中，我们将探讨ASD管理中的炎症状况、神经免疫相互作用功能障碍以及免疫系统治疗方法。
