Allen C, Stetz D, Roman S H, Podos S, Som P, Davies T F
J Clin Endocrinol Metab. 1985 Jul;61(1):183-7. doi: 10.1210/jcem-61-1-183.
We investigated an unselected series of 55 patients with treated or untreated hyperthyroid Graves' disease, assessing their clinical and laboratory status and ophthalmological findings, including the difference in intraocular pressure (dIOP) between upgaze and straight gaze using applanation tonometry. An increased dIOP (greater than 2 mm Hg) was detected in only 22% of Graves' patients [who had a mean dIOP of 3.5 +/- 1.6 (+/- SEM) mm Hg]. dIOP did not correlate with age, sex, age at disease onset, duration of disease, mode of antithyroid treatment, or thyroid function testing at the time of examination. Mean Hertel exophthalmometry measurements in patients with a dIOP greater than 2 mm Hg were 22.0 +/- 2.9 mm compared with 18.4 +/- 3.7 mm in those with a dIOP less than 2 mm Hg (P less than 0.027, by Wilcoxon rank sum test). Only 58% of patients with increased dIOP had clinical exophthalmos, but all had other evidence of Graves' eye disease. Computed tomographic scanning revealed significant proptosis and/or orbital muscle involvement in all of the patients with increased dIOP.
我们对55例接受过治疗或未接受过治疗的甲状腺功能亢进型格雷夫斯病患者进行了一项非选择性研究，评估他们的临床和实验室状况以及眼科检查结果，包括使用压平眼压计测量上视和直视时的眼压差异（dIOP）。仅22%的格雷夫斯病患者检测到dIOP升高（大于2 mmHg）[这些患者的平均dIOP为3.5±1.6（±SEM）mmHg]。dIOP与年龄、性别、发病年龄、病程、抗甲状腺治疗方式或检查时的甲状腺功能测试均无相关性。dIOP大于2 mmHg的患者平均Hertel突眼测量值为22.0±2.9 mm，而dIOP小于2 mmHg的患者为18.4±3.7 mm（通过Wilcoxon秩和检验，P小于0.027）。dIOP升高的患者中只有58%有临床突眼，但所有患者都有格雷夫斯眼病的其他证据。计算机断层扫描显示，所有dIOP升高的患者均有明显的眼球突出和/或眼眶肌肉受累。
