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爱泼斯坦-巴尔病毒DNA中的重复序列与散布在人类染色体上的细胞DNA序列相关。

Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes.

作者信息

Heller M, Henderson A, Kieff E

出版信息

Proc Natl Acad Sci U S A. 1982 Oct;79(19):5916-20. doi: 10.1073/pnas.79.19.5916.

DOI:10.1073/pnas.79.19.5916
PMID:6310555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347021/
Abstract

The third internal repeat (IR3) simple repeat array in Epstein-Barr virus (EBV) DNA has a high degree of homology to a reiterated component of cell DNAs. 32P-Labeled human or mouse DNAs hybridize to the IR3 sequence on Southern blots of viral DNA. EBV IR3 probe identifies many restriction enzyme fragments on Southern blots of human and mouse DNAs that have extensive homology to IR3. Cytological hybridization shows that IR3 is homologous to at least one region on each human chromosome except the Y chromosome.

摘要

爱泼斯坦-巴尔病毒（EBV）DNA中的第三个内部重复序列（IR3）简单重复阵列与细胞DNA的一个重复组分具有高度同源性。在病毒DNA的Southern印迹上，用32P标记的人或小鼠DNA与IR3序列杂交。EBV IR3探针在人及小鼠DNA的Southern印迹上可识别许多与IR3具有广泛同源性的限制性酶切片段。细胞杂交显示，IR3与除Y染色体外的每个人类染色体上的至少一个区域同源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd56/347021/7e1321b17a94/pnas00458-0169-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd56/347021/62a34b69b523/pnas00458-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd56/347021/228616208c41/pnas00458-0167-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd56/347021/b1a8ffbf1e08/pnas00458-0167-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd56/347021/d324e3580917/pnas00458-0167-g.jpg
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本文引用的文献

1
Enemies within: the genesis of retrovirus oncogenes.体内的敌人：逆转录病毒癌基因的起源
Cell. 1981 Jan;23(1):5-6. doi: 10.1016/0092-8674(81)90263-4.
2
Transforming DNA integrates into the host chromosome.转化DNA整合到宿主染色体中。
Cell. 1981 Jan;23(1):29-39. doi: 10.1016/0092-8674(81)90267-1.
3
Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis.通过荧光免疫电泳和放射免疫电泳鉴定爱泼斯坦-巴尔病毒核抗原。
人丙氨酸：乙醛酸转氨酶基因内含子中一个多态性串联重复序列的分子特征及临床应用
Hum Genet. 1994 Jul;94(1):55-64. doi: 10.1007/BF02272842.
4
Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.爱泼斯坦-巴尔病毒、传染性单核细胞增多症与移植后淋巴细胞增殖性疾病
Transplant Sci. 1994 Sep;4(1):61-79.
5
Production of human monoclonal IgG antibodies against Rhesus (D) antigen.抗恒河猴（D）抗原的人单克隆IgG抗体的制备。
Proc Natl Acad Sci U S A. 1984 May;81(10):3214-7. doi: 10.1073/pnas.81.10.3214.
6
Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis.类风湿关节炎患者血液中爱泼斯坦-巴尔病毒感染的B细胞频率异常升高。
J Clin Invest. 1984 Jun;73(6):1789-95. doi: 10.1172/JCI111388.
7
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Two distant clusters of partially homologous small repeats of Epstein-Barr virus are transcribed upon induction of an abortive or lytic cycle of the virus.在诱导爱泼斯坦-巴尔病毒的流产性或裂解性周期时，该病毒的两个远距离部分同源小重复序列簇会被转录。
J Virol. 1983 Dec;48(3):731-43. doi: 10.1128/JVI.48.3.731-743.1983.
9
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J Immunol. 1981 Aug;127(2):585-90.
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Nucleic Acids Res. 1980 Dec 20;8(24):5949-64. doi: 10.1093/nar/8.24.5949.
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Epstein-Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line.爱泼斯坦-巴尔病毒RNA。V。在严格感染、生长转化的细胞系中的病毒RNA。
J Virol. 1980 Nov;36(2):506-18. doi: 10.1128/JVI.36.2.506-518.1980.
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