用异源病毒DNA的一个小克隆亚片段进行基因转移后，潜伏性爱泼斯坦-巴尔疱疹病毒表达的激活。
Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.
作者信息
Countryman J, Miller G
出版信息
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4085-9. doi: 10.1073/pnas.82.12.4085.
Abstract
We previously found that a form of Epstein-Barr virus with rearranged DNA induces replication of latent Epstein-Barr virus. We now have found that one of three fragments of this rearranged DNA, when cloned in recombinant plasmids and used to transfect cells, can activate expression of several polypeptides from a latent viral genome. The 33-kDa protein that is the product of the active fragment is likely to be responsible for disruption of latency.
摘要
我们之前发现，一种DNA重排的爱泼斯坦-巴尔病毒形式可诱导潜伏性爱泼斯坦-巴尔病毒的复制。我们现在发现，这种重排DNA的三个片段之一，当克隆到重组质粒中并用于转染细胞时，可激活潜伏病毒基因组中几种多肽的表达。活性片段产生的33 kDa蛋白可能是导致潜伏期中断的原因。
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