Phillips Siobhan M, Stampfer Meir J, Chan June M, Giovannucci Edward L, Kenfield Stacey A
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA,
J Cancer Surviv. 2015 Sep;9(3):500-11. doi: 10.1007/s11764-015-0426-2. Epub 2015 Apr 16.
Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer. We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics.
Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) were prospectively examined in men diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-up Study (n = 1917) using generalized linear models.
After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, <0.0001). Effects were small (d = 0.16-0.20) but approached clinical significance for men in the highest vs. lowest activity categories. Survivors who walked ≥ 90 min/week at a normal pace, or faster, reported higher hormone/vitality scores (p = 0.001) than men walking <90 min at an easy pace. Weightlifting was associated with increased urinary incontinence (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in men who were ≥ 5 years post-treatment, had more advanced disease (Gleason score ≥ 7), and had ≥ 1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL.
Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in ≥ 5 h of non-vigorous activity or ≥ 3 h of walking per week may be beneficial.
Encouraging men to engage in non-vigorous activity and walking may be helpful for managing prostate cancer-related HRQOL.
许多前列腺癌幸存者因前列腺癌而出现健康相关生活质量（HRQOL）受损的情况。我们研究了活动类型和强度以及久坐行为与前列腺癌相关HRQOL之间的关系，总体情况以及按人口统计学、疾病和治疗特征进行分析。
在健康专业人员随访研究中，对1917名被诊断为非转移性前列腺癌的男性，使用广义线性模型前瞻性地研究诊断后活动和久坐行为与HRQOL领域（尿失禁、尿道刺激/梗阻、肠道、性功能以及活力/激素）之间的关联。
在调整潜在混杂因素后，总活动、非剧烈活动和步行活动的持续时间越长，活力/激素功能得分越高（p趋势，<0.0001）。效应较小（d = 0.16 - 0.20），但在最高与最低活动类别中的男性中接近临床意义。以正常或更快速度每周步行≥90分钟的幸存者报告的激素/活力得分（p = 0.001）高于以轻松速度步行<90分钟的男性。举重与尿失禁增加相关（p趋势，0.02）。总活动与治疗后≥5年、疾病进展更严重（ Gleason评分≥7）且有≥1种合并症的男性的更高激素/活力功能相关。未观察到剧烈活动或久坐行为与HRQOL之间的关系。
诊断后非剧烈活动和步行时间的增加与更好的激素/活力功能呈正相关。具体而言，每周进行≥5小时的非剧烈活动或≥3小时的步行可能有益。
鼓励男性进行非剧烈活动和步行可能有助于管理与前列腺癌相关的HRQOL。
