Barrenberg Eva, Knopf Hildtraud, Garbe Edeltraut
Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraße 30, 28359 Bremen, Germany.
Department of Epidemiology and Health Monitoring, Robert Koch-Institute, General-Pape-Straße 62-66, 12101 Berlin, Germany.
Pharmacy (Basel). 2018 Jun 7;6(2):52. doi: 10.3390/pharmacy6020052.
In order to assess the effects of prescription-only (Rx) to over-the-counter (OTC) drug switches and related policies, it is imperative to distinguish self-medication from OTC drug use. The objective of this study was to estimate the OTC drug use in the adult population in Germany, to identify its predictors and to highlight methodological differences when compared to the study of a self-medication prevalence. Seven-day prevalence of OTC drug use was calculated on the basis of information provided by 7091 participants of the German Health Interview and Examination Survey for Adults (DEGS1) conducted between 2008 to 2011. Logistic regression analysis was used to identify predictors of OTC drug use. Seven-day prevalence of OTC drug use was higher in women (47.16%) than in men (33.17%). Female gender, an age of more than 60 years, reduced health status, Rx drug use, and multi-morbidity were identified as predictors of OTC drug use. The levels of OTC drug use were higher than the self-medication prevalence found in the same data set probably because some OTC drugs are commonly prescribed by physicians. Drug utilization studies should, therefore, make a methodological distinction between self-medication and OTC drug use depending on whether the focus is on drug safety or the impact of regulatory decisions on the trade status.
为了评估处方药转换为非处方药以及相关政策的影响,区分自我药疗和非处方药使用至关重要。本研究的目的是估计德国成年人群中非处方药的使用情况,确定其预测因素,并突出与自我药疗患病率研究相比的方法学差异。基于2008年至2011年期间进行的德国成人健康访谈与检查调查(DEGS1)的7091名参与者提供的信息,计算了非处方药使用的七日患病率。采用逻辑回归分析来确定非处方药使用的预测因素。女性非处方药使用的七日患病率(47.16%)高于男性(33.17%)。女性、年龄超过60岁、健康状况下降、使用处方药以及患有多种疾病被确定为非处方药使用的预测因素。非处方药的使用水平高于同一数据集中发现的自我药疗患病率,这可能是因为一些非处方药通常由医生开出处方。因此,药物利用研究应根据重点是药物安全性还是监管决策对贸易状况的影响,在自我药疗和非处方药使用之间进行方法学区分。