Mucsi I, Prágai B M
Experientia. 1985 Jul 15;41(7):930-1. doi: 10.1007/BF01970018.
The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields of Human (alpha) herpesvirus 1 (HSV-1) and Suid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral activity and cAMP-enhancing effect were dependent on the concentrations of the flavonoids, and these effects turned out to be parallel. This study suggests that a relation exists between the antiviral effect and the cAMP-enhancing activity of flavonoids.
在细胞培养中研究了四种黄酮类化合物对病毒增殖的抑制作用及其对细胞内环磷酸腺苷（cAMP）水平的影响。槲皮素和芦丁降低了人1型单纯疱疹病毒（HSV-1）和猪1型疱疹病毒（伪狂犬病病毒）的产量，但橙皮苷和芦丁没有效果。此外，槲皮素和芦丁提高了细胞内cAMP水平，而橙皮苷和芦丁没有改变cAMP水平。抗病毒活性和cAMP增强作用均取决于黄酮类化合物的浓度，且这些作用呈现平行关系。该研究表明黄酮类化合物的抗病毒作用与cAMP增强活性之间存在关联。
