Laboratory of Electrophysiology of Epithelial Tissue and Skin, Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Pestic Biochem Physiol. 2018 Jun;148:144-150. doi: 10.1016/j.pestbp.2018.04.011. Epub 2018 Apr 25.
Deltamethrin can be absorbed into the respiratory tract, the gastrointestinal tract and through the skin. The study was designed to assess the effect of deltamethrin on electrophysiological parameters of rabbit's skin, studied in vitro, to identify the mechanism of action and effects of short-term dermal exposure to deltamethrin. The objective of the study was to investigate changes in electrophysiological parameters after exposure to 0.01 M deltamethrin under unchanged conditions, in the presence of amiloride (sodium transport blocker) and bumetanide (chloride transport blocker). Exposure to deltamethrin reduced the electrophysiological reaction of examined tissue in unchanged conditions and during the sodium reabsorption phase but did not influence the chloride ion secretion phase. The presented data show that the pyrethroide affects transepithelial ion transport in the external layers of the skin. The inhibition of chloride and sodium ions enabled evaluation of the impact of the pesticide on dermal transport.
溴氰菊酯可通过呼吸道、胃肠道和皮肤被吸收。本研究旨在评估溴氰菊酯对兔皮肤电生理参数的影响，进行体外研究，以确定其作用机制和短期经皮暴露于溴氰菊酯的影响。本研究的目的是研究在不变条件下、阿米洛利（钠离子转运阻断剂）和布美他尼（氯离子转运阻断剂）存在下，接触 0.01 M 溴氰菊酯后电生理参数的变化。接触溴氰菊酯降低了未改变条件下以及钠离子重吸收阶段检测组织的电生理反应，但不影响氯离子分泌阶段。所提供的数据表明，拟除虫菊酯类化合物会影响皮肤外层的跨上皮离子转运。氯离子和钠离子的抑制作用可评估杀虫剂对皮肤转运的影响。
