Truong Lillian, Zheng Yun-Min, Song Tengyao, Tang Yi, Wang Yong-Xiao
Department of Molecular and Cellular Physiology, Albany Medical College, 47 New Scotland Avenue (MC8), Albany, NY, 12208, USA.
Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, 12208, USA.
Clin Transl Med. 2018 Jun 11;7(1):16. doi: 10.1186/s40169-018-0194-5.
Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like metal-binding domains, known as the Yippee domain. The YPEL family proteins are located at the centrosome adjacent to the nucleolus during interphase and mitotic apparatus during mitosis. Due to its subcellular localization, it is believed that YPEL4 may have an important role in the cell cycle and proliferation. Recent studies have shown the involvement of YPEL4 in biological processes such as the mitogen-activated protein kinase pathway and adrenal cell proliferation. Research on YPEL4 up to date also suggests that YPEL4 is a very important player in pulmonary diseases.
YPEL4 may regulate the mitogen-activated protein kinase signaling pathway to mediate adrenal cell proliferation; this molecule is also likely to be a very important player in pulmonary diseases. Although the function of YPEL4 is largely unknown, further research may substantiate the functional importance and underlying molecular processes in pulmonary and other diseases that would allow YPEL4 to become a therapeutic target.
人类类Yippee-4（YPEL4）是YPEL基因家族的成员。该家族被认为是首个高度保守的基因家族，其编码的蛋白质含有假定的锌指样金属结合结构域，即Yippee结构域。YPEL家族蛋白在间期位于靠近核仁的中心体，在有丝分裂期位于有丝分裂器。由于其亚细胞定位，人们认为YPEL4可能在细胞周期和增殖中发挥重要作用。最近的研究表明YPEL4参与了诸如丝裂原活化蛋白激酶途径和肾上腺细胞增殖等生物学过程。迄今为止对YPEL4的研究还表明，YPEL4在肺部疾病中是一个非常重要的参与者。
YPEL4可能调节丝裂原活化蛋白激酶信号通路以介导肾上腺细胞增殖；该分子也可能是肺部疾病中一个非常重要的参与者。尽管YPEL4的功能在很大程度上尚不清楚，但进一步的研究可能会证实其在肺部和其他疾病中的功能重要性及潜在分子过程，这将使YPEL4成为一个治疗靶点。
