miR-155在人类结肠癌中的表达上调。

Up-regulated expression of miR-155 in human colonic cancer.

作者信息

Cao Hongliang, Huang Shaojun, Liu Aihua, Chen Zhidan

机构信息

Department of General Surgery, Affiliated Xiangyang Central Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, P.R. China.

Department of Clinical Laboratory, Affiliated Xiangyang Central Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, P.R. China.

出版信息

J Cancer Res Ther. 2018 Apr-Jun;14(3):604-607. doi: 10.4103/0973-1482.175432.

DOI:10.4103/0973-1482.175432

PMID:29893326

Abstract

OBJECTIVE

The aim of this study is to investigate the expression of miR-155 in colonic cancer tissue and to assess the potential predictive value of miR-155 in colonic cancer patients.

MATERIALS AND METHODS

From March to September of 2011, we included 57 patients with primary colonic cancer who underwent curative surgical resection. Total RNAs were extracted from colonic cancer tissues and adjacent normal tissues. Then the expression of miR-155 in colonic cancer and paracancerous tissues was investigated using real time quantitative reverse transcription-polymerase chain reaction. And the relationship between miR-155 expression level and the clinical, pathological parameters of colonic cancer was analyzed.

RESULTS

The relative expression level of miR-155 in colonic cancer tissues was significantly higher than that in paracancerous tissues and related to tumor-node-metastasis staging, tumor invasion, metastasis, and differentiation.

CONCLUSION

The expression of miR-155 is up-regulated in colonic cancer tissues. MiR-155 may acts as proto-oncogenes involved in carcinogenesis, development, and invasion of colon cancer making it a potential target for gene therapy of colon cancer.

摘要