Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark; email:
Annu Rev Anal Chem (Palo Alto Calif). 2018 Jun 12;11(1):197-218. doi: 10.1146/annurev-anchem-061417-125811.
Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed.
在医学、环境科学、生物防御和农业领域，人们强烈需要对食品和饮料中的细菌污染以及基因改造生物体进行核酸（NAs）的灵敏、特异和快速分析。电化学分析为开发此类分析平台提供了准确、简单、经济和强大的工具，这些平台在核酸检测方面可以与其他方法成功竞争。本文综述和批判性讨论了 DNA 的电极反应、电化学核酸分析的基本原理及其在实际应用中的相关性。
