Yoon Kijung, Ryu Seungho, Lee Jieun, Park Jung-Duck
Occupation and Health Research Center, Ridgewood, New Jersey, United States.
Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Diabetes Metab Syndr. 2018 Nov;12(6):977-983. doi: 10.1016/j.dsx.2018.06.008. Epub 2018 Jun 6.
To determine whether hs-CRP level and interval change of hs-CRP could predict the development of metabolic abnormalities in healthy subjects in a longitudinal study.
A cohort of 3748 male who had normal hs-CRP level without evidence of any component of metabolic syndrome were studied. At each visit, hs-CRP level and metabolic abnormalities were measured. Interval change of hs-CRP for each subject was calculated. COX proportional hazard model and logistic regression analysis were used.
Cumulative incidence and incidence density of metabolic syndrome were 3.96% and 7.17 per 1000 person-year, respectively. Cumulative incidence of metabolic syndrome was significantly increased according to hs-CRP tertile level. This significance remained after adjusting age, smoking, drinking, and exercise. Although the hazard ratio of metabolic syndrome for incidence density was increased significantly as hs-CRP increased, such trend disappeared after adjusting for confounding variables. The risk of metabolic syndrome was significantly higher (1.48 times) in the hs-CRP increased group than that in the decreased or unchanged group. This significance remained after controlling for covariates.
Relatively higher hs-CRP level within normal range may predict the increase of metabolic syndrome compared to lower hs-CRP. Increased hs-CRP level may increase the incidence of metabolic syndrome.
在一项纵向研究中确定超敏C反应蛋白（hs-CRP）水平及其变化是否能够预测健康受试者代谢异常的发生。
对3748名hs-CRP水平正常且无代谢综合征任何组分证据的男性进行队列研究。每次随访时，测量hs-CRP水平和代谢异常情况。计算每位受试者hs-CRP的变化值。采用COX比例风险模型和逻辑回归分析。
代谢综合征的累积发病率和发病密度分别为3.96%和每1000人年7.17例。根据hs-CRP三分位数水平，代谢综合征的累积发病率显著增加。在调整年龄、吸烟、饮酒和运动因素后，这种显著性仍然存在。虽然随着hs-CRP升高，代谢综合征发病密度的风险比显著增加，但在调整混杂变量后，这种趋势消失。hs-CRP升高组代谢综合征的风险显著更高（1.48倍），高于hs-CRP降低或不变组。在控制协变量后，这种显著性仍然存在。
与较低的hs-CRP相比，正常范围内相对较高的hs-CRP水平可能预示着代谢综合征的增加。hs-CRP水平升高可能增加代谢综合征的发病率。
