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影响体外冲击波碎石术治疗尿路结石疗效的因素

Factors Affecting the Outcome of Extracorporeal Shockwave Lithotripsy in Urinary Stone Treatment.

作者信息

Shinde Sanjay, Al Balushi Younis, Hossny Medhat, Jose Sachin, Al Busaidy Salma

机构信息

Urology Department, Armed Forces Hospital, Muscat, Oman.

Planning and Studies Department, Oman Medical Specialty Board, Muscat, Oman.

出版信息

Oman Med J. 2018 May;33(3):209-217. doi: 10.5001/omj.2018.39.

Abstract

OBJECTIVES

We sought to evaluate the factors affecting the outcome of extracorporeal shockwave lithotripsy (ESWL) in urinary stone treatment.

METHODS

We conducted a retrospective review of 235 adult patients treated with ESWL, for radiopaque renal or ureteric stones between January 2015 and December 2016. Patient's age, sex, stone size, laterality, location, density, skin-to-stone distance (SSD), and presence of double J stent were studied as potential predictors. At the end of three months, the patients were divided into success and failure groups and the significance was determined.

RESULTS

Of the 235 patients (188 males and 47 females) analyzed, ESWL was successful in 79.1%. Univariate analysis of both groups revealed no significant difference in patient's age and stone laterality. Statistically significant differences in gender, stone size, stone site, stone density, SSD, and patients with stents were observed. Statistically significant factors in multivariate logistic regression analysis were sex and stent. Females had three-times higher risk for ESWL failure than males (odds ratio (OR) = 3.213; 95% confidence interval (CI): 1.194-8.645; 0.021) and a higher failure rate when a stent was used (OR = 6.358; 95% CI: 2.228-18.143; 0.001).

CONCLUSIONS

This study revealed that ESWL can treat renal and ureteric stones successfully with an inverse association between outcome and predictors such as stone size and density, SSD, and stent presence. These factors can help us in improving patient selection and ensure better results at lower cost.

摘要

目的

我们旨在评估影响体外冲击波碎石术(ESWL)治疗尿路结石效果的因素。

方法

我们对2015年1月至2016年12月期间接受ESWL治疗不透X线肾结石或输尿管结石的235例成年患者进行了回顾性研究。研究了患者的年龄、性别、结石大小、侧别、位置、密度、皮肤至结石距离(SSD)以及双J支架的置入情况,将其作为潜在预测因素。在三个月末,将患者分为成功组和失败组并确定其显著性。

结果

在分析的235例患者(188例男性和47例女性)中,ESWL成功率为79.1%。两组的单因素分析显示患者年龄和结石侧别无显著差异。观察到性别、结石大小、结石部位、结石密度、SSD以及置入支架的患者存在统计学显著差异。多因素逻辑回归分析中的统计学显著因素为性别和支架。女性ESWL失败风险是男性的三倍(比值比(OR)=3.213;95%置信区间(CI):1.194 - 8.645;P = 0.021),使用支架时失败率更高(OR = 6.358;95%CI:2.228 - 18.143;P = 0.001)。

结论

本研究表明ESWL能够成功治疗肾和输尿管结石,且治疗效果与结石大小、密度、SSD以及支架置入等预测因素呈负相关。这些因素有助于我们优化患者选择,以更低成本确保更好的治疗效果。

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