a National Institute for Health Research, Bristol Biomedical Research Centre, University of Bristol , Bristol , UK.
b Translational Health Sciences, Bristol Medical School, Southmead Hospital, University of Bristol , Bristol , UK.
Ann Med. 2018 Aug;50(5):437-442. doi: 10.1080/07853890.2018.1489143. Epub 2018 Jul 24.
We sought to determine cross-sectional and longitudinal associations of frequency of sauna bathing with high sensitivity C-reactive protein (hsCRP), fibrinogen, leucocyte count and gamma-glutamyltransferase (GGT).
Baseline sauna bathing habits were assessed in 2269 men aged 42-61 years. Concentrations of hsCRP, fibrinogen, leucocyte count, and GGT were determined at baseline and 11 years later. The associations of sauna bathing frequency with baseline and 11-year hsCRP, fibrinogen, leucocyte count, and GGT levels were examined using robust multivariate regression analyses.
In baseline analysis, 4-7 sauna sessions/week (compared with 1 sauna session/week) was associated with -0.84 mg/l (95% CI, -1.55, -0.14; p = .019) lower hsCRP; -0.07 g/l (95% CI, -0.15, 0.02; p = .112) lower fibrinogen; and -0.28 × 10/l (95% CI, -0.51, -0.06; p = .015) lower leucocyte count, after multivariable adjustment. In longitudinal analysis, the corresponding estimates were -1.66 mg/l (95% CI, -3.13, -0.19; p = .027); -0.16 g/l (95% CI, -0.31, -0.02; p = .031); and -0.49 × 10/l (95% CI, -0.85, -0.14; p = .007) respectively. Sauna bathing frequency was not associated with GGT at baseline and 11 years.
Observational evidence supports the hypothesis that reduction in inflammation may be one of the pathways linking frequent sauna bathing with decreased risk of acute and chronic disease conditions. KEY MESSAGES Cross-sectional evidence or short-term studies suggest Finnish sauna bathing may exert its beneficial health effects via reduction in inflammation and oxidative stress; however, the long-term effects of sauna bathing on these outcomes are uncertain. In this population-based prospective cohort study, frequent sauna sessions significantly decreased levels of inflammatory markers at baseline and 11-year follow-up; but had no effect on oxidative stress. The health benefits of sauna bathing may in part be mediated via reduced systemic inflammation.
本研究旨在确定芬兰浴（sauna bathing）频率与高敏 C 反应蛋白（hsCRP）、纤维蛋白原、白细胞计数和γ-谷氨酰转移酶（GGT）之间的横断面和纵向关联。
本研究共纳入 2269 名年龄在 42-61 岁的男性，在基线时评估他们的芬兰浴习惯。在基线和 11 年后分别检测 hsCRP、纤维蛋白原、白细胞计数和 GGT 的浓度。使用稳健的多变量回归分析来检验芬兰浴频率与基线和 11 年 hsCRP、纤维蛋白原、白细胞计数和 GGT 水平之间的关联。
在基线分析中，与每周洗 1 次桑拿相比，每周洗 4-7 次桑拿与 hsCRP 降低 0.84mg/L（95%CI：-1.55，-0.14；p=0.019）、纤维蛋白原降低 0.07g/L（95%CI：-0.15，0.02；p=0.112）和白细胞计数降低 0.28×10/L（95%CI：-0.51，-0.06；p=0.015）有关，经多变量调整后。在纵向分析中，相应的估计值分别为-1.66mg/L（95%CI：-3.13，-0.19；p=0.027）、-0.16g/L（95%CI：-0.31，-0.02；p=0.031）和-0.49×10/L（95%CI：-0.85，-0.14；p=0.007）。基线和 11 年后，芬兰浴频率与 GGT 均无关联。
观察性证据支持以下假设，即减少炎症可能是频繁洗芬兰浴与降低急性和慢性疾病风险之间的关联途径之一。
横断面证据或短期研究表明，芬兰浴可能通过降低炎症和氧化应激来发挥其有益的健康效应；然而，桑拿浴对这些结果的长期影响尚不确定。在这项基于人群的前瞻性队列研究中，频繁的桑拿浴显著降低了基线和 11 年随访时的炎症标志物水平；但对氧化应激没有影响。桑拿浴的健康益处可能部分通过降低全身炎症来介导。
