Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Magn Reson Imaging. 2018 Aug;48(2):301-317. doi: 10.1002/jmri.26161. Epub 2018 Jun 13.
Iron has long been implicated in many neurological and other organ diseases. It is known that over and above the normal increases in iron with age, in certain diseases there is an excessive iron accumulation in the brain and liver. MRI is a noninvasive means by which to image the various structures in the brain in three dimensions and quantify iron over the volume of the object of interest. The quantification of iron can provide information about the severity of iron-related diseases as well as quantify changes in iron for patient follow-up and treatment monitoring. This article provides an overview of current MRI-based methods for iron quantification, specifically for the brain and liver, including: signal intensity ratio, R , R2*, R2', phase, susceptibility weighted imaging and quantitative susceptibility mapping (QSM). Although there are numerous approaches to measuring iron, R and R2* are currently preferred methods in imaging the liver and QSM has become the preferred approach for imaging iron in the brain.
5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018. J. MAGN. RESON. IMAGING 2018;48:301-317.
铁长期以来一直与许多神经和其他器官疾病有关。众所周知，除了随着年龄的增长而正常增加的铁之外，在某些疾病中，大脑和肝脏中的铁过度积累。磁共振成像是一种非侵入性的方法，可以三维成像大脑中的各种结构，并定量感兴趣对象的体积中的铁。铁的定量可以提供有关铁相关疾病严重程度的信息，以及量化铁的变化，以进行患者随访和治疗监测。本文概述了目前基于 MRI 的铁定量方法，特别是针对大脑和肝脏，包括：信号强度比、R、R2*、R2'、相位、磁化率加权成像和定量磁化率映射（QSM）。尽管有许多测量铁的方法，但 R 和 R2* 目前是肝脏成像的首选方法，而 QSM 已成为大脑中成像铁的首选方法。
5 技术功效：第 5 阶段 J.磁共振成像 2018. J.磁共振成像 2018;48:301-317.
