Hornstein M J, Jupeau A M, Scavizzi M R, Philippon A M, Grimont P A
Antimicrob Agents Chemother. 1985 May;27(5):806-11. doi: 10.1128/AAC.27.5.806.
The MICs of 21 beta-lactam antibiotics were measured against 126 clinically significant and epidemiologically unrelated Yersinia enterocolitica isolates. The most active antimicrobial agents tested (geometric means of MICs) were ceftriaxone, cefotaxime, ceftizoxime, and cefmenoxime (0.06 to 0.08 micrograms/ml). Mezlocillin (1.36 micrograms/ml) and piperacillin (1.57 micrograms/ml) were the most active penicillins. Aztreonam and imipenem had MICs of 0.44 and 0.24 micrograms/ml. All isolates exhibited some degree of resistance against ampicillin (MICs, greater than or equal to 4 micrograms/ml) and cephalothin (MICs, greater than or equal to 8 micrograms/ml). Cephalosporinase or penicillinase activities were expressed by all isolates. A principal component analysis of MIC data separated the major serotypes (O3, O9, O8, and O5,27). The MCBs of 14 newer beta-lactams were measured against 10 clinical isolates. On the basis of the ratio of MBC to MIC (expressed in dilution factors), a real bactericidal activity was only observed for imipenem (MBC/MIC = 1). For the other newer beta-lactams, the ratios ranged from 4 to 8.
测定了21种β-内酰胺类抗生素对126株具有临床意义且在流行病学上无关联的小肠结肠炎耶尔森菌分离株的最低抑菌浓度（MIC）。所测试的最具活性的抗菌药物（MIC的几何均值）为头孢曲松、头孢噻肟、头孢唑肟和头孢甲肟（0.06至0.08微克/毫升）。美洛西林（1.36微克/毫升）和哌拉西林（1.57微克/毫升）是最具活性的青霉素。氨曲南和亚胺培南的MIC分别为0.44和0.24微克/毫升。所有分离株对氨苄西林（MIC≥4微克/毫升）和头孢噻吩（MIC≥8微克/毫升）均表现出一定程度的耐药性。所有分离株均表达头孢菌素酶或青霉素酶活性。对MIC数据进行主成分分析可区分主要血清型（O3、O9、O8和O5,27）。测定了14种新型β-内酰胺类抗生素对10株临床分离株的最低杀菌浓度（MBC）。根据MBC与MIC的比值（以稀释倍数表示），仅观察到亚胺培南具有真正的杀菌活性（MBC/MIC = 1）。对于其他新型β-内酰胺类抗生素，该比值范围为4至8。
