Cookson W O, Musk A W, Glancy J J, de Klerk N H, Yin R, Mele R, Carr N G, Armstrong B K, Hobbs M S
Br J Ind Med. 1985 Jul;42(7):461-8. doi: 10.1136/oem.42.7.461.
The survival of 354 claimants for compensation for pulmonary asbestosis among former workers of the Wittenoom crocidolite mine and mill in Western Australia has been examined. There were 118 deaths up to December 1982. The median time between start of work and claim for compensation was 17 years. The standardised mortality ratio (SMR) for deaths from all causes was 2.65 (p less than 0.0001). The SMR for pneumoconiosis was 177.2 (p less than 0.0001), bronchitis and emphysema 2.6 (p = 0.04), tuberculosis 44.6 (p less than 0.0001), respiratory cancer (including five deaths from malignant pleural mesothelioma) 6.4 (p less than 0.0001), gastrointestinal cancer 1.6 (p = 0.22), all other cancers 1.6 (p = 0.17), heart disease 1.4 (p = 0.07), and all other causes 2.18 (p = 0.004). Plain chest radiographs taken within two years of claiming compensation were found for 238 subjects and were categorised independently by two observers according to the International Labour Organisation criteria without knowledge of exposure or compensation details. Profusion of radiographic opacities, age at claiming compensation, work in the Wittenoom mill, and degree of disability awarded by the pneumoconiosis medical board were significant predictors of survival, but total estimated exposure to asbestos was not. Radiographic profusion and degree of disability were, however, predictable by total exposure. The median survival from claim for compensation was 17 years in subjects with ILO category 1 pneumoconiosis, 12 years in category 2, and three years in category 3.
对西澳大利亚州维特努姆青石棉矿和加工厂的354名石棉肺索赔者的存活情况进行了调查。截至1982年12月,有118人死亡。开始工作至提出索赔的中位时间为17年。所有原因导致的死亡的标准化死亡比(SMR)为2.65(p<0.0001)。尘肺病的SMR为177.2(p<0.0001),支气管炎和肺气肿为2.6(p=0.04),肺结核为44.6(p<0.0001),呼吸道癌症(包括5例恶性胸膜间皮瘤死亡)为6.4(p<0.0001),胃肠道癌症为1.6(p=0.22),所有其他癌症为1.6(p=0.17),心脏病为1.4(p=0.07),所有其他原因导致的死亡为2.18(p=0.004)。在238名受试者中发现了索赔后两年内拍摄的胸部X光平片,两名观察者在不知道暴露或赔偿细节的情况下根据国际劳工组织标准独立进行分类。X光片阴影的密集程度、索赔时的年龄、在维特努姆工厂的工作经历以及尘肺病医疗委员会判定的残疾程度是存活的重要预测因素,但石棉总暴露量不是。然而,X光片阴影密集程度和残疾程度可由总暴露量预测。国际劳工组织分类为1期尘肺病的受试者从索赔起的中位生存期为17年,2期为12年,3期为3年。