补充蜜蜂花对慢性稳定型心绞痛患者抑郁、焦虑、压力和睡眠障碍的影响。
The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina.
作者信息
Haybar Habib, Javid Ahmad Zare, Haghighizadeh Mohammad Hosein, Valizadeh Einollah, Mohaghegh Seyede Marjan, Mohammadzadeh Assieh
机构信息
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Clin Nutr ESPEN. 2018 Aug;26:47-52. doi: 10.1016/j.clnesp.2018.04.015. Epub 2018 May 19.
BACKGROUND
Despite advances in the treatment of cardiovascular diseases in recent decades, patients experience high levels of depression, anxiety, stress, and insomnia. Since the calming effect of Melissa officinalis (MO) has been known, this study aimed to determine the effects of MO supplementation on depression, anxiety, stress, and sleep disturbances in patients with chronic stable angina (CSA).
METHODS
In this double-blind placebo-controlled clinical trial, 80 patients with CSA were divided randomly into two groups (taking 3 g MO supplement or placebo daily for 8 weeks). The shortened 21-item version of the depression, anxiety and stress scale (DASS-21) test and Pittsburgh sleep quality index were done before and after the intervention.
RESULTS
At the end of the study, the intervention group receiving MO capsules had a significant reduction in scores of depression, anxiety, stress, and total sleep disturbance, compared with the placebo group (P < 0.05).
CONCLUSIONS
The results showed that 8-week supplementation with 3 g MO can decrease depression, anxiety, stress, and sleep disorder in patients with CSA.
背景
尽管近几十年来心血管疾病的治疗取得了进展，但患者仍存在高度的抑郁、焦虑、压力和失眠。由于已知蜜蜂花（MO）具有镇静作用，本研究旨在确定补充MO对慢性稳定型心绞痛（CSA）患者的抑郁、焦虑、压力和睡眠障碍的影响。
方法
在这项双盲安慰剂对照临床试验中，80例CSA患者被随机分为两组（每天服用3克MO补充剂或安慰剂，持续8周）。在干预前后进行了简化的21项抑郁、焦虑和压力量表（DASS-21）测试以及匹兹堡睡眠质量指数评估。
结果
研究结束时，与安慰剂组相比，接受MO胶囊的干预组在抑郁、焦虑、压力和总睡眠障碍评分方面有显著降低（P < 0.05）。
结论
结果表明，3克MO补充剂持续8周可降低CSA患者的抑郁、焦虑、压力和睡眠障碍。
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