Huygen K, Mascart-Lemone F, Cran S, Van de Perre P, Henrivaux P, De Ley M, Clumeck N
Eur J Clin Microbiol. 1985 Jun;4(3):304-9. doi: 10.1007/BF02013658.
Serum interferon and in vitro production of alpha and gamma interferon by peripheral blood leucocytes were examined in 21 African patients with acquired immunodeficiency syndrome (AIDS) and in 15 African patients with AIDS-related complex. Interferon was detected in the serum of 44% of the patients with AIDS-related complex and in 70% of the patients with full-blown AIDS, and was characterized as an acid-labile alpha interferon. When compared to healthy blood donors, the interferon response of peripheral blood leucocytes to Newcastle Disease virus was impaired in 7 of 12 patients with AIDS-related complex and in 16 of 20 AIDS patients (p less than 0.005). Also, production of gamma interferon following stimulation with phytohaemagglutinin was diminished in 5 of 11 patients with AIDS-related complex and in 13 of 17 patients with AIDS (p less than 0.005). A high correlation was observed between the presence of circulating interferon and decreased in vitro production of gamma interferon, but not of alpha interferon. These results suggest that the impairment of in vitro production of gamma interferon can be used as a preclinical marker of AIDS.
对21例非洲获得性免疫缺陷综合征（AIDS）患者和15例非洲艾滋病相关综合征患者的血清干扰素以及外周血白细胞体外产生α和γ干扰素的情况进行了检测。在44%的艾滋病相关综合征患者和70%的典型艾滋病患者血清中检测到了干扰素，其特征为酸不稳定的α干扰素。与健康献血者相比，12例艾滋病相关综合征患者中有7例以及20例艾滋病患者中有16例，外周血白细胞对新城疫病毒的干扰素反应受损（p<0.005）。此外，11例艾滋病相关综合征患者中有5例以及17例艾滋病患者中有13例，在受到植物血凝素刺激后γ干扰素的产生减少（p<0.005）。观察到循环干扰素的存在与γ干扰素而非α干扰素体外产生减少之间存在高度相关性。这些结果表明，γ干扰素体外产生受损可作为艾滋病的临床前标志物。
