Department of Electronic Engineering, Kwangwoon University, Seoul, Republic of Korea.
Department of Electronic Engineering, Kwangwoon University, Seoul, Republic of Korea.
Biosens Bioelectron. 2018 Oct 15;117:267-275. doi: 10.1016/j.bios.2018.06.008. Epub 2018 Jun 5.
Electroplating of nanoporous Pt (nPt) induces an extremely strong tensile stress, which results in the exfoliation of nPt on flexible polymer substrate despite plasma treatment to improve adhesion. Here, we overcame this challenge by modifying flexible stainless-steel, and developed wearable, robust, flexible, and non-enzymatic continuous glucose monitoring system. The flexible stainless-steel was highly effective in improving the adhesion between the metal layer and substrate. The developed wireless system included electrochemical analysis circuits, a microcontroller unit, and a wireless communication module. Finally, we evaluated the continuous glucose monitoring system through two animal testing, by implanting into subcutaneous tissue and measuring interstitial fluid (ISF) glucose values at 5-15-min intervals. Comparison of the measured ISF glucose with blood glucose determined by the Clarke error grid analysis showed that 82.76% of the measured glucose was within zone A. Furthermore, the wearable glucose sensor exhibited bio-compatible to implant through various bio-compatibility tests.
电沉积纳米多孔铂 (nPt) 会引起极强的拉伸应力，即使经过等离子体处理以提高附着力，也会导致 nPt 从柔性聚合物基底剥落。在这里，我们通过修饰柔性不锈钢克服了这一挑战，并开发了可穿戴、坚固、灵活且无需酶的连续葡萄糖监测系统。柔性不锈钢在改善金属层与基底之间的附着力方面非常有效。所开发的无线系统包括电化学分析电路、微控制器单元和无线通信模块。最后，我们通过两次动物试验对连续葡萄糖监测系统进行了评估，将其植入皮下组织并以 5-15 分钟的间隔测量间质液 (ISF) 中的葡萄糖值。通过 Clarke 误差网格分析对测量的 ISF 葡萄糖与血液葡萄糖进行比较，结果表明，82.76%的测量葡萄糖值位于区域 A 内。此外，可穿戴葡萄糖传感器通过各种生物相容性测试显示出对植入的生物兼容性。
