早产儿脐血样本中血浆蛋白质组的变化。
Plasma proteome changes in cord blood samples from preterm infants.
机构信息
Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
Department of Neonatology and Intensive Care Warsaw Medical University, Warsaw, Poland.
出版信息
J Perinatol. 2018 Sep;38(9):1182-1189. doi: 10.1038/s41372-018-0150-7. Epub 2018 Jun 18.
OBJECTIVE
In the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants.
STUDY DESIGN
Preterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition.
RESULT
Preterm delivery is associated with multiple protein abundance changes in plasma related to a plethora of processes, including inflammation and immunomodulation, coagulation, and complement activation as some key features.
CONCLUSION
Plasma proteome analysis revealed numerous gestation-age-dependent protein abundance differences between term and preterm infants, which highlight key dysregulated pathways and potential new protein treatment targets.
目的
在本研究中，我们旨在通过对早产儿的脐带血样本进行分层，系统分析其血浆蛋白质组，以鉴定出生时可能导致早产儿并发症的蛋白质及其相关功能障碍途径。
研究设计
将早产儿分为三个不同胎龄亚组进行研究：分别出生于≤26 周（第 1 组）、27-28 周（第 2 组）和 29-30 周（第 3 组）的新生儿，并与健康、足月新生儿的对照组进行血浆蛋白质组组成比较。
结果
早产与血浆中多种与多种过程相关的蛋白质丰度变化有关，包括炎症和免疫调节、凝血和补体激活等一些关键特征。
结论
血浆蛋白质组分析揭示了足月和早产儿之间存在许多与胎龄相关的蛋白质丰度差异，突出了关键失调途径和潜在的新蛋白质治疗靶点。
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