Letunica Natasha, Cai Tengyi, Cheong Jeanie L Y, Doyle Lex W, Monagle Paul, Ignjatovic Vera
Haematology Research Laboratory, Murdoch Children's Research Institute, Parkville, Australia.
Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Parkville, Australia.
Clin Proteomics. 2021 Apr 14;18(1):13. doi: 10.1186/s12014-021-09316-y.
Over the last decade, the use of proteomics in the setting of prematurity has increased and has enabled researchers to successfully identify biomarkers for an array of associated morbidities. The objective of this scoping review was to identify the existing literature, as well as any knowledge gaps related to proteomic biomarker discoveries in the setting of prematurity. A scoping review was conducted using PubMed, Embase and Medline databases following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The study selection process yielded a total of 700 records, of which 13 studies were included in this review. Most studies used a tandem Mass Spectrometry (MS/MS) proteomics approach to identify key biomarkers. The corresponding studies identified proteins associated with retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotising enterocolitis (NEC), late onset sepsis (LOS) and gestational age. This scoping review demonstrates the limited use of proteomics to identify biomarkers associated with severe complications of prematurity. Further research is warranted to identify biomarkers of other important morbidities associated with prematurity, such as intraventricular haemorrhage (IVH) and cerebral palsy, and to investigate the mechanisms associated with these outcomes.
在过去十年中，蛋白质组学在早产领域的应用有所增加，使研究人员能够成功识别一系列相关疾病的生物标志物。本范围综述的目的是识别现有文献以及与早产环境中蛋白质组学生物标志物发现相关的知识空白。按照系统评价和Meta分析扩展的范围综述（PRISMA-ScR）指南，使用PubMed、Embase和Medline数据库进行了范围综述。研究选择过程共产生700条记录，其中13项研究纳入本综述。大多数研究采用串联质谱（MS/MS）蛋白质组学方法来识别关键生物标志物。相应研究确定了与早产儿视网膜病变（ROP）、支气管肺发育不良（BPD）、坏死性小肠结肠炎（NEC）、晚发性败血症（LOS）和胎龄相关的蛋白质。本范围综述表明，蛋白质组学在识别与早产严重并发症相关的生物标志物方面应用有限。有必要进一步开展研究，以识别与早产相关的其他重要疾病（如脑室内出血（IVH）和脑瘫）的生物标志物，并研究与这些结果相关的机制。
