Department of Neurology, JingJiang People's Hospital, No. 28, Zhongzhou Road, Jingjiang, CN 214500, Jiangsu, China.
Department of Clinical Pharmacy, JingJiang People's Hospital, No. 28, Zhongzhou Road, Jingjiang, CN 214500, Jiangsu, China.
BMC Geriatr. 2018 Jun 19;18(1):146. doi: 10.1186/s12877-018-0837-9.
The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) is widely used as a complementary screening tool for dementia. However, there are few studies concerning the efficacy of the IQCODE for assessing the severity of cognitive impairments in patients with Alzheimer's disease (AD). We aimed to evaluate the efficacy of the IQCODE for assessing the severity of dementia in patients with AD.
According to the clinical dementia rating (CDR), 394 patients with AD were enrolled and classified into three groups: mild, moderate and severe groups. The IQCODE scores of each group were determined by interviewing the informants with the short version of the 16-item IQCODE. The correlations of the IQCODE score with the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale (DRS) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) were analysed. Statistical analyses were conducted to examine the differences in the IQCODE scores among the three groups.
The validity coefficients of the IQCODE with the MMSE, DRS and ADAS-Cog were - 0.528, - 0.436, and 0.477, respectively. The sensitivity was 66.1%, and the specificity was 59.8% when using a cut-off score of 65 to discriminate between mild-moderate dementia. When 75 was used as the threshold between moderate-severe dementia, the sensitivity and the specificity were 73.9 and 67.7%, respectively.
The IQCODE is moderately effective for assessing the severity of cognitive impairment in patients with AD.
简易智能精神状态检查量表（MMSE）是一种广泛应用于痴呆症的补充筛查工具。然而，关于 MMSE 评估阿尔茨海默病（AD）患者认知障碍严重程度的疗效的研究较少。我们旨在评估 MMSE 评估 AD 患者痴呆严重程度的疗效。
根据临床痴呆评定量表（CDR），共纳入 394 例 AD 患者，并分为三组：轻度、中度和重度组。由知情人用 16 项 MMSE 简短版访谈确定每组的 MMSE 评分。分析 MMSE 评分与简易精神状态检查量表（MMSE）、马修斯痴呆评定量表（DRS）和阿尔茨海默病评估量表认知分量表（ADAS-Cog）的相关性。进行统计学分析，以检验三组之间 MMSE 评分的差异。
MMSE 与 MMSE、DRS 和 ADAS-Cog 的效度系数分别为-0.528、-0.436 和 0.477。当使用 65 作为区分轻度至中度痴呆的截断值时，灵敏度为 66.1%，特异性为 59.8%。当将 75 作为中度至重度痴呆的阈值时，灵敏度和特异性分别为 73.9%和 67.7%。
MMSE 评估 AD 患者认知障碍严重程度的效果中等。
