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用单克隆抗体分析二氧化硅粉尘的免疫效应。

Immunological effect of silica dust analyzed by monoclonal antibodies.

作者信息

Youinou P, Ferec C, Cledes J, Zabbe C, Philippon P, Dewitte J D, Guillerm D, Clavier J

出版信息

J Clin Lab Immunol. 1985 Apr;16(4):207-10.

PMID:2991527
Abstract

We found a significant decrease of OKT8 + ve cells in silicosis patients (18.1%), but also in unaffected exposed workers (19.0%), when compared with sex- and age-matched controls (22.8%). The proportion of OKT8 + ve cells was significantly lower in subjects with antinuclear antibodies (15.7%) and in those with IgG-rheumatoid factors (16.3%).

摘要

我们发现,与年龄和性别匹配的对照组(22.8%)相比,矽肺患者(18.1%)以及未受影响的暴露工人(19.0%)体内OKT8阳性细胞显著减少。抗核抗体阳性受试者(15.7%)和IgG类风湿因子阳性受试者(16.3%)体内OKT8阳性细胞的比例显著较低。

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Immunological effect of silica dust analyzed by monoclonal antibodies.用单克隆抗体分析二氧化硅粉尘的免疫效应。
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引用本文的文献

1
ANCA-associated diseases and silica exposure.抗中性粒细胞胞浆抗体相关疾病与二氧化硅暴露
Clin Rev Allergy Immunol. 1997 Spring;15(1):21-40. doi: 10.1007/BF02828275.
2
Histocompatibility antigens in a population based silicosis series.基于人群的矽肺系列中的组织相容性抗原
Br J Ind Med. 1989 Jun;46(6):364-9. doi: 10.1136/oem.46.6.364.
3
Antibody producing cells in the spleens of mice treated with pathogenic mineral dust.用致病性矿物粉尘处理的小鼠脾脏中的抗体产生细胞。
Br J Ind Med. 1989 Oct;46(10):724-8. doi: 10.1136/oem.46.10.724.