人类T细胞白血病病毒I型x-lor基因在大肠杆菌中的表达。
Expression of the x-lor gene of human T-cell leukemia virus I in Escherichia coli.
作者信息
Goh W C, Sodroski J, Rosen C, Haseltine W
出版信息
J Virol. 1985 Aug;55(2):497-9. doi: 10.1128/JVI.55.2.497-499.1985.
Abstract
The 3'-terminal regions of the human T-cell leukemia virus I (HTLV-I) and HTLV-II genomes encode a novel gene product. We showed that expression of this region fused to the beta-galactosidase gene in bacteria produces a protein recognized by adult T-cell leukemia-lymphoma patient sera. Rabbit antibodies raised against this protein specifically precipitated the 42-kilodalton x-lor gene protein from HTLV-I-infected cells.
摘要
人类T细胞白血病病毒I型（HTLV-I）和HTLV-II基因组的3'末端区域编码一种新的基因产物。我们发现，该区域与细菌中的β-半乳糖苷酶基因融合表达产生的一种蛋白质能被成人T细胞白血病-淋巴瘤患者血清识别。针对这种蛋白质产生的兔抗体能特异性地从感染HTLV-I的细胞中沉淀出42千道尔顿的x-lor基因蛋白。
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