鼠白血病病毒感染的组织选择性由长末端重复序列决定。
Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences.
作者信息
Rosen C A, Haseltine W A, Lenz J, Ruprecht R, Cloyd M W
出版信息
J Virol. 1985 Sep;55(3):862-6. doi: 10.1128/JVI.55.3.862-866.1985.
Abstract
Here we show that the tissue specificity of murine retrovirus infections is determined by the long terminal repeat (LTR) of an otherwise isogenic set of viruses. The isogenic viruses used for this study contain the coding gag, pol, and env genes of the avirulent Akv virus. Recombinant viruses that contain the LTR of a virus that induces T-cell leukemia lymphoma preferentially infect T lymphocytes. Viruses that carry the LTR of a virus that induces erythroleukemia preferentially infect non-T lymphoblastoid cell lines in the marrow and spleen. The Akv virus itself displays no tissue preference for hematopoietic cells. These experiments suggest that retroviruses that carry appropriate enhancer-promoters can be used to infect selectively specific target cells in animals.
摘要
在此我们表明，鼠逆转录病毒感染的组织特异性由一组同基因病毒的长末端重复序列（LTR）决定。本研究中使用的同基因病毒含有无毒Akv病毒的编码gag、pol和env基因。含有诱导T细胞白血病淋巴瘤病毒LTR的重组病毒优先感染T淋巴细胞。携带诱导红白血病病毒LTR的病毒优先感染骨髓和脾脏中的非T淋巴母细胞系。Akv病毒本身对造血细胞没有组织偏好。这些实验表明，携带适当增强子-启动子的逆转录病毒可用于选择性感染动物体内特定的靶细胞。
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