非洲病毒性出血热检测移动实验室的开发。
Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa.
机构信息
Institute of Aquaculture, University of Stirling, Scotland, United Kingdom.
Arbovirus Unit, Pasteur Institute, Dakar, Senegal.
出版信息
J Infect Dis. 2018 Oct 5;218(10):1622-1630. doi: 10.1093/infdis/jiy362.
BACKGROUND
A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks.
METHODS
The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase amplification. In this study, we describe various stages of the mobile laboratory development.
RESULTS
A brief overview of mobile laboratory deployments, which culminated in the first on-site detection of Ebola virus disease (EVD) in March 2014, and their successful use in a campaign to roll back EVD cases in Conakry in the West Africa Ebola virus outbreak are described.
CONCLUSIONS
The developed mobile laboratory successfully enabled local teams to perform rapid disgnostic testing for viral hemorrhagic fever.
背景
为了能够对病毒性出血热疫情做出本地响应，开发了一种可搭乘商业航班运输的移动实验室。
方法
该实验室从使用移动实时逆转录聚合酶链反应发展到使用移动实时重组酶聚合酶扩增。在这项研究中，我们描述了移动实验室开发的各个阶段。
结果
本文简要概述了移动实验室的部署情况，它们最终促成了 2014 年 3 月首次在现场检测到埃博拉病毒病（EVD），并在西非埃博拉病毒疫情期间在科纳克里开展的消除埃博拉病毒病例的运动中成功使用。
结论
开发的移动实验室成功地使本地团队能够进行病毒性出血热的快速诊断测试。
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