Jackson James Ds, Cotton Sarah E, Bruce Wirta Sara, Proenca Catia C, Zhang Milun, Lahoz Raquel, Calado Frederico J
Real World Research, Adelphi Real World, Bollington, UK.
Real World Evidence, Cardio-Metabolics Franchise, Novartis Sweden AB, Stockholm, Sweden.
Drug Des Devel Ther. 2018 Jun 8;12:1659-1668. doi: 10.2147/DDDT.S148949. eCollection 2018.
Little evidence exists on the burden that chronic heart failure (HF) poses specifically to patients in China. The objective of this study, therefore, was to describe the burden of HF on patients in China.
A cross-sectional survey of cardiologists and their patients with HF was conducted. Patient record forms were completed by 150 cardiologists for 10 consecutive patients. Patients for whom a patient record form was completed were invited to complete a patient questionnaire.
Most of the 933 patients (mean [SD] age 65.8 [10.2] years; 55% male; 80% retired) included in the study received care in tier 2 and 3 hospitals in large cities. Patients gave a median score of 4 on a scale from 1 (no disruption) to 10 (severe disruption) to describe how much HF disrupts their everyday life. Patients in paid employment (8%) missed 10% of work time and experienced 29% impairment in their ability to work due to HF in the previous week. All aspects of patients' health-related quality of life (QoL) were negatively affected by their condition. Mean ± SD utility calculated by the 3-level 5-dimension EuroQol questionnaire was 0.8±0.2, and patients rated their health at 70.3 (11.5) on a 100 mm visual analog scale. Patients incurred costs associated with HF treatment, travel, and professional caregiving services.
HF is associated with poor health-related QoL and considerable disruption in patients' lives. Novel and improved therapies are needed to reduce the burden of HF on patients and the health care system.
关于慢性心力衰竭(HF)对中国患者造成的负担,现有证据较少。因此,本研究的目的是描述HF对中国患者的负担。
对心脏病专家及其HF患者进行了横断面调查。150名心脏病专家连续为10名患者填写患者记录表。完成患者记录表的患者被邀请填写患者问卷。
纳入研究的933名患者中,大多数(平均[标准差]年龄65.8[10.2]岁;55%为男性;80%已退休)在大城市的二级和三级医院接受治疗。患者在1(无干扰)至10(严重干扰)的量表上给出的中位数评分为4,以描述HF对其日常生活的干扰程度。有带薪工作的患者(8%)在前一周因HF错过了10%的工作时间,工作能力受损29%。患者健康相关生活质量(QoL)的各个方面均受到病情的负面影响。通过三级五维度欧洲生活质量调查问卷计算的平均±标准差效用值为0.8±0.2,患者在100毫米视觉模拟量表上对自身健康的评分是70.3(11.5)。患者产生了与HF治疗、交通和专业护理服务相关的费用。
HF与健康相关QoL较差以及患者生活受到相当大的干扰有关。需要新的和改进的治疗方法来减轻HF对患者和医疗保健系统的负担。