Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, University of Copenhagen, Rigshospitalet, Valdemar Hansens Vej 6, DK-2600, Glostrup, Denmark.
i2minds, Møllegade, 32, Aarhus, Denmark.
Eur J Pediatr. 2018 Sep;177(9):1309-1315. doi: 10.1007/s00431-018-3192-0. Epub 2018 Jun 20.
We estimated the long-term socioeconomic consequences and health care costs of Neisseria meningitidis meningitis (NM). The prospective cohort study included Danish individuals with onset of NM in childhood and adolescence, diagnosed between 1980 and 2009. Health care costs and socioeconomic data were obtained from nationwide administrative and health registers. Two thousand nine hundred two patients were compared with 11,610 controls matched for age, gender, and other sociodemographic characteristics. In the follow-up analysis at the age of 30 years, 1028 patients were compared with 4452 controls. We found that (1) NM caused increased mortality at disease onset, but after adequate treatment, the mortality rate was similar to that of the general population; (2) neurological and eye diseases were more frequently observed in patients; (3) patients had significantly lower grade-point averages; (4) patients had lower income even when transfer payments were taken into account; and (5) patients' initial health care costs were elevated.Conclusion: NM has significant influence on mortality, morbidity, education, and income. We suggest that the management of patients with previous meningococcal meningitis should focus on early educational and social interventions to improve social and health outcomes. What is known: • Meningococcal meningitis is a severe infectious disease affecting children and adolescents with high rates of mortality and complications. What is new: • Meningococcal meningitis causes increased mortality at disease onset, but after adequate treatment the mortality rate is similar to that of the general population. • Meningococcal meningitis in childhood and adolescence has a major long-term effect on morbidity, health care costs, education, employment, and income.
我们评估了脑膜炎奈瑟菌（Nm）脑膜炎的长期社会经济后果和医疗保健成本。这项前瞻性队列研究纳入了丹麦在儿童和青少年时期发病的 Nm 患者，其诊断时间为 1980 年至 2009 年。医疗保健成本和社会经济数据来自全国性的行政和健康登记处。将 2902 名患者与 11610 名按年龄、性别和其他社会人口统计学特征匹配的对照组进行比较。在 30 岁时的随访分析中，将 1028 名患者与 4452 名对照组进行比较。我们发现：（1）Nm 在发病时导致死亡率升高，但经过充分治疗后，死亡率与普通人群相似；（2）神经和眼部疾病在患者中更为常见；（3）患者的平均绩点明显较低；（4）即使考虑到转移支付，患者的收入也较低；（5）患者的初始医疗保健费用较高。结论：Nm 对死亡率、发病率、教育和收入有重大影响。我们建议，对既往脑膜炎奈瑟菌脑膜炎患者的管理应侧重于早期教育和社会干预，以改善社会和健康结果。已知：•脑膜炎奈瑟菌是一种严重的传染病，影响儿童和青少年，死亡率和并发症发生率高。新发现：•Nm 在发病时导致死亡率升高，但经过充分治疗后，死亡率与普通人群相似。•儿童和青少年时期的脑膜炎奈瑟菌对发病率、医疗保健成本、教育、就业和收入有重大的长期影响。
