微流控技术辅助的免疫磁纳米材料的合理设计及其对液体活检的形状效应。
Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy.
机构信息
Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA.
出版信息
Lab Chip. 2018 Jul 10;18(14):1997-2002. doi: 10.1039/c8lc00273h.
Abstract
Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.
摘要
微流控为纳米材料的合成带来了独特的机遇，有助于实现高效的液体活检。在此，我们通过简单地调整流速，开发了基于微反应器的免疫磁性纳米材料的流动合成方法，可控制备具有可控形状（球形、立方体、棒状和带状）的免疫磁性纳米材料。首次研究了粒子形状对循环肿瘤细胞的筛选效率，并与商业铁磁流体进行了比较，为基于颗粒体系的循环肿瘤标志物筛选和分析的合理设计提供了新的见解。
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