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本文引用的文献

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Microfluidics-mediated self-template synthesis of anisotropic hollow ellipsoidal mesoporous silica nanomaterials.微流控介导的各向异性中空椭球形介孔二氧化硅纳米材料的自模板合成
Mater Res Lett. 2017;5(8):584-590. doi: 10.1080/21663831.2017.1376720. Epub 2017 Sep 14.
2
Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels.微流控螺旋通道中超快速合成多功能亚微米空心二氧化硅球
Sci Rep. 2017 Oct 3;7(1):12616. doi: 10.1038/s41598-017-12856-9.
3
Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications - a review.用于生物医学应用的微流控平台可控合成功能纳米颗粒——综述
Lab Chip. 2017 Jan 17;17(2):209-226. doi: 10.1039/c6lc01049k.
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Shape matters when engineering mesoporous silica-based nanomedicines.当工程介孔硅基纳米药物时，形状很重要。
Biomater Sci. 2016 Apr;4(4):575-91. doi: 10.1039/c5bm00589b. Epub 2016 Jan 28.
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EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.转移性乳腺癌中循环肿瘤细胞的EpCAM非依赖性富集
PLoS One. 2015 Dec 22;10(12):e0144535. doi: 10.1371/journal.pone.0144535. eCollection 2015.
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Microfluidic devices to enrich and isolate circulating tumor cells.用于富集和分离循环肿瘤细胞的微流控装置。
Lab Chip. 2015 Dec 21;15(24):4500-11. doi: 10.1039/c5lc00947b. Epub 2015 Nov 9.
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Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array.利用微磁阵列对单个循环肿瘤细胞进行筛选及分子分析
Sci Rep. 2015 Nov 5;5:16047. doi: 10.1038/srep16047.
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Shape-Controlled Synthesis of Magnetic Iron Oxide@SiO₂-Au@C Particles with Core-Shell Nanostructures.具有核壳纳米结构的磁性氧化铁@二氧化硅-金@碳颗粒的形状控制合成
Langmuir. 2015 May 12;31(18):5190-7. doi: 10.1021/acs.langmuir.5b00800. Epub 2015 Apr 28.
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Microscale magnetic field modulation for enhanced capture and distribution of rare circulating tumor cells.用于增强稀有循环肿瘤细胞捕获和分布的微尺度磁场调制
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Challenges in circulating tumour cell research.循环肿瘤细胞研究中的挑战。
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微流控技术辅助的免疫磁纳米材料的合理设计及其对液体活检的形状效应。

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy.

机构信息

Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA.

出版信息

Lab Chip. 2018 Jul 10;18(14):1997-2002. doi: 10.1039/c8lc00273h.

DOI:10.1039/c8lc00273h
PMID:29923569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6071334/
Abstract

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

摘要

微流控为纳米材料的合成带来了独特的机遇，有助于实现高效的液体活检。在此，我们通过简单地调整流速，开发了基于微反应器的免疫磁性纳米材料的流动合成方法，可控制备具有可控形状（球形、立方体、棒状和带状）的免疫磁性纳米材料。首次研究了粒子形状对循环肿瘤细胞的筛选效率，并与商业铁磁流体进行了比较，为基于颗粒体系的循环肿瘤标志物筛选和分析的合理设计提供了新的见解。