三齿萼距花根中的柏烷二萜类化合物及其对一氧化氮的抑制活性。
Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities.
出版信息
J Nat Prod. 2018 Jul 27;81(7):1508-1516. doi: 10.1021/acs.jnatprod.7b00814. Epub 2018 Jun 20.
Twelve new abietane diterpenoids (1-12) and 31 known analogues (13-43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1-3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC values of 5.6-16.1 μM. The structure-activity relationships of the isolated diterpenoids are also estimated.
从药用中国草药罗勒（Clerodendrum trichotomum Thunberg）中分离得到了 12 种新的松香二萜（1-12）和 31 种已知类似物（13-43）。根据 ECD 和 X 射线晶体学数据确定了 1-3 的绝对构型，而 4 的构型则通过比较实验和计算 ECD 数据得到阐明。八种二萜，15,16-脱氢特乌烯酮 G（1）、三托明 A（4）、2α-羟基 Caryopincaolide F（7）、villosin C（20）、15-去氢-17-羟基 Cyrtophyllone A（22）、去甲基 cryptojaponol（38）、6β-羟基去甲基 cryptojaponol（39）和三托酮（43）对 NO 产生具有抑制作用，IC 值为 5.6-16.1 μM。还估计了分离出的二萜的结构-活性关系。
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