van Netten J P, Algard F T, Coy P, Carlyle S J, Brigden M L, Thornton K R, Peter S, Fraser T, To M P
Cancer. 1985 Oct 15;56(8):2019-24. doi: 10.1002/1097-0142(19851015)56:8<2019::aid-cncr2820560822>3.0.co;2-4.
Twenty-six surgical breast cancer specimens were subjected to multiple estrogen receptor (ER) assays with a microsample technique. In most tumors there were large variations in ER levels in samples taken from different regions of the same tumor. After correction of individual samples for differences in carcinoma content, such variations were not abolished. Nine of the 26 breast cancers, although positive overall, were devoid of ER in some regions. For ER-positive tumors the average coefficient of variation (CV) for intratumor ER levels was 86%, with a range from 25% to 200%. This is well above the CV obtained with repeat samples of homogeneous tissue (14%). These results suggest that many ER-positive cancers may be composed of cells with a variety of ER levels. An assessment of individual intratumor ER variability may have biologic and clinical significance.
对26个手术切除的乳腺癌标本采用微量样本技术进行了多次雌激素受体（ER）检测。在大多数肿瘤中，取自同一肿瘤不同区域的样本中ER水平存在很大差异。在对各个样本的癌组织含量差异进行校正后，这种差异并未消除。26例乳腺癌中有9例虽然总体呈阳性，但在某些区域没有ER。对于ER阳性肿瘤，瘤内ER水平的平均变异系数（CV）为86%，范围为25%至200%。这远高于用均匀组织重复样本获得的CV（14%）。这些结果表明，许多ER阳性癌症可能由具有不同ER水平的细胞组成。评估肿瘤内个体ER变异性可能具有生物学和临床意义。
