Spadea Leopoldo, Tonti Emanuele, Spaterna Andrea, Marchegiani Andrea
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Veterinary Teaching Hospital, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Case Rep Ophthalmol. 2018 May 24;9(2):287-298. doi: 10.1159/000488846. eCollection 2018 May-Aug.
Conjunctivitis, keratoconjunctivitis, and corneal ulcers are common eye disorders frequently diagnosed in both humans and animals, and are currently treated by topical administration of eye drops containing anti-inflammatory and antibacterial agents. The current molecules often lack efficacy because infections in hypoxic tissue contain methicillin-resistant and ; thus, new products for the treatment of ocular pain and inflammation are needed. The use of ozone, a molecule stabilized for topical use as an ozonide, could be providential due to its anti-inflammatory and bactericidal activity in certain anterior segment pathologies, in addition to promoting tissue repair properties. Ozonated oils have the same properties as gaseous ozone and are well tolerated by tissues. In the present study the repair and regeneration effect of ozonated oil in liposomes plus hypromellose (Ozodrop®, FB Vision, Ascoli Piceno, Italy) instilled 3-4 times a day in external ocular spontaneous pathologies both in animals and humans are reported.
结膜炎、角膜结膜炎和角膜溃疡是人和动物中常见的眼部疾病,目前通过局部使用含有抗炎和抗菌剂的眼药水进行治疗。目前的药物往往缺乏疗效,因为缺氧组织中的感染含有耐甲氧西林菌,因此,需要用于治疗眼部疼痛和炎症的新产品。臭氧作为一种以臭氧化物形式稳定用于局部的分子,由于其在某些眼前节病变中的抗炎和杀菌活性,以及促进组织修复的特性,可能会带来福音。臭氧油具有与气态臭氧相同的特性,并且组织耐受性良好。在本研究中,报告了每天3-4次向动物和人类的外眼自发性病变中滴注脂质体加羟丙甲纤维素的臭氧油(Ozodrop®,FB Vision,意大利阿斯科利皮切诺)的修复和再生效果。