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脂质体臭氧油在眼部感染中的应用：临床前和临床研究综述，重点关注其抗菌和再生特性

Liposomal Ozonated Oil in Ocular Infections: A Review of Preclinical and Clinical Studies, Focusing on Its Antiseptic and Regenerative Properties.

作者信息

Pérez-Santonja Juan J, Güell José Luis, Gris Oscar, Vázquez Dorrego Xose Manuel, Pellicer Esther, Benítez-Del-Castillo Jose Manuel

机构信息

Department of Ophthalmology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.

Department of Cornea and Refractive Surgery, Institut de Microcirurgia Ocular (IMO), Barcelona, Spain.

出版信息

Clin Ophthalmol. 2022 Jun 14;16:1953-1962. doi: 10.2147/OPTH.S360929. eCollection 2022.

DOI:10.2147/OPTH.S360929
PMID:35726319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9206455/
Abstract

Ozonated oil has shown antimicrobial, anti-inflammatory and regenerative properties that make it useful in the prevention of infectious diseases and also as an adjuvant in wound-healing management. This review brings together most aspects of the use of liposomal ozonated oil for ocular infections and regeneration of the ocular surface. A search was performed in PubMed, Medline, Web of Science and Cochrane Library for studies published by June 2021. Search terms were combined to sort out papers on the properties and use of ozonated oil in ocular infections. A total of 25 publications were selected for this review on the composition, mechanism of action, restorative action, and preclinical and clinical studies of liposomal ozonated oil focused on ocular infections. In patients with complicated corneal pathology, liposomal ozonated oil has been found to restore corneal ulcers and improve keratitis. In patients with ocular pathologies involving inflammation and infections, liposomal ozonated oil has been found to improve and almost completely restore the signs of vernal, granulomatous and even adenoviral conjunctivitis. Liposomal ozonated oil has also been found to be effective in reducing ocular microbial flora. In conclusion, liposomal ozonated oil has an antiseptic and regenerative effect on corneoconjunctival tissues. It has demonstrated efficacy and safety profile for its use in ocular infections and can be considered as a suitable supportive strategy both alone and combined with other antimicrobial agents.

摘要

臭氧油已显示出抗菌、抗炎和再生特性，使其可用于预防传染病，并作为伤口愈合管理的辅助剂。本综述汇集了脂质体臭氧油用于眼部感染和眼表再生的大多数方面。在PubMed、Medline、科学网和考克兰图书馆中检索了截至2021年6月发表的研究。组合检索词以筛选出关于臭氧油在眼部感染中的特性和用途的论文。总共选择了25篇关于脂质体臭氧油的组成、作用机制、修复作用以及针对眼部感染的临床前和临床研究的出版物进行本综述。在患有复杂角膜病变的患者中，已发现脂质体臭氧油可修复角膜溃疡并改善角膜炎。在患有涉及炎症和感染的眼部疾病的患者中，已发现脂质体臭氧油可改善并几乎完全恢复春季卡他性、肉芽肿性甚至腺病毒性结膜炎的体征。还发现脂质体臭氧油在减少眼部微生物菌群方面有效。总之，脂质体臭氧油对角膜结膜组织具有防腐和再生作用。它已证明在眼部感染中的使用具有有效性和安全性，可单独或与其他抗菌剂联合作为一种合适的支持策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/45f80802bad9/OPTH-16-1953-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/1ddbe2568b61/OPTH-16-1953-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/0f50e166ef1f/OPTH-16-1953-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/e63738ff51e8/OPTH-16-1953-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/894a34b705a1/OPTH-16-1953-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/9e84b6ef0af4/OPTH-16-1953-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/45f80802bad9/OPTH-16-1953-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/1ddbe2568b61/OPTH-16-1953-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/0f50e166ef1f/OPTH-16-1953-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/e63738ff51e8/OPTH-16-1953-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/894a34b705a1/OPTH-16-1953-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/9e84b6ef0af4/OPTH-16-1953-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/9206455/45f80802bad9/OPTH-16-1953-g0006.jpg

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本文引用的文献

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Microb Biotechnol. 2022 May;15(5):1422-1433. doi: 10.1111/1751-7915.13949. Epub 2021 Nov 12.
2
Ozone-Based Eye Drops Activity on Ocular Epithelial Cells and Potential Pathogens Infecting the Front of the Eye.基于臭氧的眼药水对眼表上皮细胞及感染眼前部的潜在病原体的活性
Antioxidants (Basel). 2021 Jun 16;10(6):968. doi: 10.3390/antiox10060968.
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Topical Liposomal Ozonated Oil in Complicated Corneal Disease: A Report on Three Clinical Cases.
脂质体臭氧油可确保玻璃体内注射前微生物负荷进一步降低：“OPERA”研究。
Ophthalmol Ther. 2024 Oct;13(10):2771-2788. doi: 10.1007/s40123-024-01006-w. Epub 2024 Aug 30.
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In praise of povidone-iodine application in ophthalmology.赞碘在眼科学中的应用。
Surv Ophthalmol. 2024 Mar-Apr;69(2):211-223. doi: 10.1016/j.survophthal.2023.11.002. Epub 2023 Nov 8.
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