Ou Tongwen, Lilly Michael, Jiang Wei
Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States.
Front Immunol. 2018 Jun 6;9:1188. doi: 10.3389/fimmu.2018.01188. eCollection 2018.
Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate tissues from prostate cancer patients, and altered TLR4 signals may promote cancer development, as well as antitumor effects. In this review, we have summarized key features of the TLR4 signaling pathway and its associated immune responses and focused on the pathologic role of TLR4 in prostate carcinogenesis and tumor progression.
Toll样受体（TLR）4在正常和恶性前列腺上皮细胞中均有表达。TLR4及其下游信号通路介导宿主针对入侵病原体的固有免疫反应。然而，多项证据表明，前列腺癌患者前列腺组织中TLR4表达增加，且TLR4信号改变可能促进癌症发展以及抗肿瘤作用。在本综述中，我们总结了TLR4信号通路的关键特征及其相关免疫反应，并重点关注TLR4在前列腺癌发生和肿瘤进展中的病理作用。
