编码αA-晶状体蛋白的基因座与小鼠第17号染色体上的H-2K紧密连锁。
The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17.
作者信息
Skow L C, Donner M E
出版信息
Genetics. 1985 Aug;110(4):723-32. doi: 10.1093/genetics/110.4.723.
Abstract
We have used a complementary DNA (cDNA) for mouse alpha A-crystallin to probe genomic DNA for restriction fragment length polymorphisms which could be used to map the alpha A-crystallin gene locus (Acry-1) in the mouse genome. Ten of 12 restriction endonucleases produced fragment polymorphism among various inbred strains of mice. A comprehensive strain survey conducted with six endonucleases resulted in the discovery of six allelic forms of Acry-1. Linkage analysis was conducted on DNA from three sets of recombinant inbred strains of mice and demonstrated close linkage of Acry-1 with the major histocompatibility complex (H-2) on chromosome 17. Analysis of congenic and recombinant congenic strains of mice confirmed the linkage of Acry-1 and H-2 and located the alpha A gene to the region between glyoxylase (Glo-1) and H-2K.
摘要
我们使用小鼠αA-晶体蛋白的互补DNA（cDNA）来探测基因组DNA中的限制性片段长度多态性，这些多态性可用于在小鼠基因组中定位αA-晶体蛋白基因座（Acry-1）。12种限制性内切酶中有10种在不同的近交系小鼠中产生了片段多态性。用6种内切酶进行的全面品系调查发现了Acry-1的6种等位基因形式。对三组重组近交系小鼠的DNA进行连锁分析，结果表明Acry-1与17号染色体上的主要组织相容性复合体（H-2）紧密连锁。对同源近交系和重组同源近交系小鼠的分析证实了Acry-1与H-2的连锁，并将αA基因定位到乙二醛酶（Glo-1）和H-2K之间的区域。
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