Vraka Irene, Panourgias Evangelia, Sifakis Emmanouil, Koureas Andreas, Galanis Petros, Dellaportas Dionysios, Gouliamos Athanasios, Antoniou Aristides
Department of Radiology, Aretaieion Hospital, Department of Medicine, National & Kapodistrian University of Athens, Athens, Greece.
Department of Oncology-Pathology, Jonas Bergh Research Group, Karolinska Institute, Stockholm, Sweden.
In Vivo. 2018 Jul-Aug;32(4):945-954. doi: 10.21873/invivo.11333.
BACKGROUND/AIM: Little is known about the correlation between contrast-enhanced ultrasound (CEUS) characteristics and pathological prognostic factors in breast cancer. The aim of this study was to explore the correlation between CEUS characteristics and pathological prognostic factors.
A retrospective study with 34 malignant breast lesions was conducted. CEUS characteristics included qualitative characteristics (e.g. lesion's enhancement degree and order, internal lesion homogeneity etc.) and quantitative characteristics (e.g. peak intensity, time to peak etc.). Also, pathological prognostic factors were included (e.g. tumor grade, estrogen receptor status etc.).
Blurred lesion margins were observed more often in tumors of high histological grade (p=0.01) and in estrogen receptor-negative tumors (p=0.049). Furthermore, perilesional enhancement was associated with positive Ki-67 expression (p=0.049), while heterogeneous internal sentinel lymph node enhancement was associated with malignant infiltration of the node (p=0.002).
CEUS has the potential to provide a prevision of pathological prognostic factors in malignant breast lesions, helping in the better early patient management.
背景/目的：关于超声造影（CEUS）特征与乳腺癌病理预后因素之间的相关性，目前所知甚少。本研究的目的是探讨CEUS特征与病理预后因素之间的相关性。
对34例乳腺恶性病变进行回顾性研究。CEUS特征包括定性特征（如病变的增强程度和顺序、病变内部均匀性等）和定量特征（如峰值强度、达峰时间等）。此外，还纳入了病理预后因素（如肿瘤分级、雌激素受体状态等）。
在高组织学分级肿瘤（p = 0.01）和雌激素受体阴性肿瘤（p = 0.049）中，更常观察到病变边缘模糊。此外，病灶周围增强与Ki-67阳性表达相关（p = 0.049），而前哨淋巴结内部不均匀增强与淋巴结恶性浸润相关（p = 0.002）。
CEUS有可能为乳腺恶性病变的病理预后因素提供预判，有助于更好地进行早期患者管理。
